DOI: https://doi.org/10.14710/jnc.v8i2.23815

PENGARUH PEMBERIAN UBI JALAR UNGU (Ipomoea batatas L. Poir) TERHADAP KADAR LEUKOSIT TOTAL TIKUS WISTAR JANTAN (Rattus norvegicus) YANG DIPAPAR ASAP ROKOK

Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro, Indonesia

Received: 14 May 2019; Published: 14 May 2019.

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Abstract

Latar belakang: Asap rokok merupakan salah satu sumber radikal bebas eksogen yang dapat menstimulasi sekresi mediator inflamasi sehingga tubuh memberikan respon inflamasi. Kadar leukosit dapat digunakan sebagai indikator untuk melihat adanya inflamasi dalam tubuh. Ubi jalar ungu diketahui mengandung antioksidan yang berpotensi mengurangi efek negatif dari radikal bebas.

Tujuan: Menganalisis pengaruh pemberian ubi jalar ungu terhadap kadar leukosit total tikus yang dipapar asap rokok.

Metode: Jenis penelitian ini adalah post-test only control group design. Besar sampel penelitian berjumlah 24 ekor tikus wistar jantan yang dibagi ke dalam 4 kelompok, yaitu kelompok K(-), kelompok K(+) yang diberi paparan asap rokok, kelompok P1 yang diberi ubi jalar ungu 8 g/200 g BB, dan kelompok P2 yang diberi paparan asap rokok serta ubi jalar ungu 8 g/200 g BB. Perlakuan dilakukan selama 30 hari. Analisis statistik menggunakan uji One-way ANOVA.

Hasil: Tidak terdapat perbedaan kadar leukosit total yang signifikan antar kelompok perlakuan (p=0,579). Kadar leukosit total tertinggi berada pada kelompok K(+) dengan nilai 23.56±3.10 x 103/mm3. Kelompok P2 memiliki kadar leukosit total sebesar 21.36±3.52 x 103/mm3.

Simpulan: Pemberian ubi jalar ungu tidak menunjukkan adanya perbedaan yang signifikan terhadap kadar leukosit total tikus yang dipapar asap rokok.

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Keywords: Ubi jalar ungu, asap rokok, leukosit total

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