DOI: https://doi.org/10.14710/jnc.v14i4.51356

POTENSI ACANTHUS ILICIFOLIUS SEBAGAI SUMBER ANTIOKSIDAN DALAM MENGELOLA STRES OKSIDATIF: TINJAUAN NARATIF

Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro, Semarang, Jawa Tengah, Indonesia

Received: 5 Jun 2025; Revised: 9 Aug 2025; Accepted: 20 Aug 2025; Available online: 30 Oct 2025; Published: 30 Oct 2025.

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Abstract

ABSTRACT

Background: Oxidative stress, resulting from an imbalance between reactive oxygen species (ROS) and antioxidant defense mechanisms, plays a critical role in the development of chronic diseases such as diabetes, cardiovascular disease, and neurodegenerative disorders. Natural antioxidants from plants are increasingly studied for their therapeutic potential.

Objective: To review the antioxidant potential of Acanthus ilicifolius (Jeruju) and its therapeutic applications in oxidative stress-related diseases.

Methods: A narrative literature review was conducted by analyzing relevant scientific articles from electronic databases focusing on in vitro, in vivo, and in silico studies of A. ilicifolius.

Results: Acanthus ilicifolius contains bioactive compounds including flavonoids, phenols, and tannins, which exhibit antioxidant, anti-inflammatory, and antimicrobial properties. Its mechanisms include ROS scavenging, enhancement of antioxidant enzyme activity, and reduction of oxidative damage. Toxicity studies indicate its extracts are generally safe at moderate doses.

Conclusion: Acanthus ilicifolius has promising potential as a functional food ingredient or therapeutic agent in managing oxidative stress-related diseases, warranting further pharmacological and clinical research.

Keywords: Acanthus ilicifolius; oxidative stress; flavonoid; antioxidant; chronic disease

 

ABSTRAK

Latar Belakang: Stres oksidatif akibat ketidakseimbangan antara spesies oksigen reaktif (ROS) dan pertahanan antioksidan berperan penting dalam patogenesis penyakit kronis seperti diabetes, penyakit kardiovaskular, dan gangguan neurodegeneratif. Antioksidan alami dari tumbuhan, semakin banyak diteliti karena potensinya dalam terapi.

Tujuan: Meninjau potensi antioksidan dari Acanthus ilicifolius (jeruju) dan aplikasinya dalam terapi penyakit terkait stres oksidatif.

Metode: Tinjauan naratif dilakukan dengan menganalisis artikel ilmiah dari berbagai basis data elektronik yang meliputi studi in vitro, in vivo, dan in silico terkait A. ilicifolius.

Hasil: Acanthus ilicifolius mengandung senyawa bioaktif seperti flavonoid, fenol, dan tanin, yang memiliki sifat antioksidan, antiinflamasi, dan antimikroba. Mekanismenya meliputi penangkapan ROS, peningkatan aktivitas enzim antioksidan, dan pengurangan kerusakan oksidatif. Studi toksisitas menunjukkan ekstraknya aman pada dosis sedang.

Kesimpulan: Acanthus ilicifolius memiliki potensi menjanjikan sebagai bahan pangan fungsional atau agen terapeutik dalam mengelola penyakit terkait stres oksidatif, dan diperlukan penelitian lebih lanjut secara farmakologis maupun klinis.

Kata kunci: Acanthus ilicifolius; stres oksidatif; flavonoid; antioksidan; penyakit kronis

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Keywords: Acanthus ilicifolius; stres oksidatif; flavonoid; antioksidan; penyakit kronis
Funding: diponegoro university

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PERAN AIR KELAPA MUDA UNTUK MENDUKUNG HIDRASI ATLET SEPAKBOLA REMAJA: NARRATIVE LITERATURE REVIEW POTENSI ACANTHUS ILICIFOLIUS SEBAGAI SUMBER ANTIOKSIDAN DALAM MENGELOLA STRES OKSIDATIF: TINJAUAN NARATIF PENGARUH PENAMBAHAN HIDROLISAT PROTEIN IKAN TERHADAP KANDUNGAN GIZI PRODUK PANGAN: TINJAUAN SISTEMATIS More recent articles
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