DOI: https://doi.org/10.14710/jnc.v14i4.44055

PENGARUH PEMBERIAN TEPUNG TOMAT (Solanum lycopersicum l) TERHADAP KADAR GLUKOSA DARAH, TRIGLISERIDA, DAN INTERLEUKIN-6 PADA TIKUS WISTAR DENGAN MODEL DIABETES MELLITUS TIPE 2

1Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro, Semarang, Jawa Tengah, Indonesia

2Departemen Pertanian, Fakultas Peternakan dan Pertanian, Universitas Diponegoro, Semarang, Jawa Tengah, Indonesia

3Departemen Kedokteran, Fakultas Kedokteran, Universitas Diponegoro, Semarang, Jawa Tengah, Indonesia

Received: 13 May 2024; Revised: 16 Jul 2025; Accepted: 20 Jul 2025; Available online: 30 Oct 2025; Published: 30 Oct 2025.

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Abstract

ABSTRACT

Background: Diabetes mellitus is a condition characterized by elevated blood glucose levels. Pro-inflammatory cytokines are damaging and cause insulin resistance. This condition results in abnormalities in lipid metabolism characterized by increased triglycerides. Tomato flour (Solanum lycopersicum) can reduce blood glucose, triglyceride and Interleukin-6 levels caused by lycopene content in tomato flour.

Objectives : The purpose of this study was to determine the effect of tomato flour on blood glucose levels, triglycerides and interleukin-6 in diabetes mellitus rats.

Methods: Post control group true experimental study. The intervention was given for 28 days to 24 Wistar rats, divided into four groups with each group totaling six rats. The dose of tomato flour 200 mg/200 g body weight of rats/day (P1), and a dose of 444 mg/200 g body weight of rats/day (P2) to rats with diabetes mellitus. The treatment groups were compared with a group of rats fed a high-fat diet (K+) and a group of healthy rats (K-). Statistical data analysis using Paired T-Test and One Way ANOVA

Results: Tomato flour showed significant differences (p<0.05) in random blood glucose, triglyceride, and IL-6 levels. The greatest reduction in blood glucose, triglyceride, and IL-6 levels occurred in the group given tomato flour at a dose of 444 mg/200 g.

Conclusion : Tomato flour dose of 222 mg/200 g body weight of rats/day and dose of 444 mg/200 g body weight of rats/day can affect blood glucose, triglyceride, and interleukin-6 levels.

Key words: Diabetes mellitus; blood glucose; interleukin-6; lycopene; tomato flour; triglycerides

 

ABSTRAK

Latar Belakang: Diabetes mellitus adalah kondisi yang ditandai dengan peningkatan kadar glukosa darah. Sitokin pro inflamasi bersifat merusak dan menyebabkan terjadi resistensi insulin. Kondisi ini mengakibatkan abnormalitas pada metabolime lipid yang ditandai dengan peningkatan trigliserida. Tepung tomat (Solanum lycopersicum) dapat menurunkan kadar glukosa darah sewaktu, trigliserida dan Interleukin-6 yang disebabkan oleh kandungan likopen pada tepung tomat.

Tujuan: Tujuan penelitian ini untuk mengetahui pengaruh tepung tomat terhadap kadar glukosa darah sewaktu, trigliserida dan IL-6 pada tikus Wistar dengan diet tinggi lemak dan mengalami diabetes mellitus.

Metode: Penelitian true eksperimental post control group. Intervensi diberikan selama 28 hari pada 24 tikus Wistar, dibagi menjadi empat kelompok dengan masing-masing kelompok berjumlah enam ekor tikus. Dosis tepung tomat 200 mg/200 g berat badan tikus/hari (P1), dan dosis 444 mg/200 g berat badan tikus/hari (P2) terhadap tikus diebets mellitus. Kelompok perlakuan dibandingkan dengan kelompok tikus yang diberi diet tinggi lemak (K+) dan kelompok tikus sehat (K-). Analisis data statistik menggunakan Uji Paired T-Test dan One Way ANOVA

Hasil: Tepung tomat menunjukkan perbedaan yang bermakna (p<0,05) pada kadar glukosa darah sewaktu, trigliserida dan IL-6. Penurunan kadar glukosa darah, trigliserida dan IL-6  paling banyak terjadi  pada kelompok pemberian tepung tomat dengan dosis 444 mg/200 g

Simpulan: Tepung tomat dosis 222 mg/200 g berat badan tikus/hari dan dosis 444 mg/200 g berat badan tikus/hari dapat berpengaruh terhadap kadar glukosa darah sewaktu, trigliserida, dan IL-6

Kata kunci: Diabetes mellitus; glukosa darah sewaktu; interleukin-6; likopen; tepung tomat; trigliserida


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Keywords: Diabetes mellitus; glukosa darah sewaktu; interleukin-6; likopen; tepung tomat; trigliserida

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