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PENGARUH PEMBERIAN AJUVAN ASAM FOLAT TERHADAP FUNGSI PERSONAL DAN SOSIAL PASIEN SKIZOFRENIA KRONIK

*Rini Suprapti orcid scopus  -  Department Psychiatry, Faculty Of Medicine Diponegoro University, Indonesia
Alifiati Fitrikasari  -  Department Psychiatry, Faculty Of Medicine Diponegoro University, Indonesia
Rihadini Pudjo  -  SMF Psikiatri, RSJD dr. Amino Gondohutomo Provinsi Jawa Tengah, Indonesia
Hang Gunawan Asikin  -  Department Psychiatry, Faculty Of Medicine Diponegoro University, Indonesia
Elly Noerhidajati  -  Department Psychiatry, Faculty Of Medicine Diponegoro University, Indonesia
Received: 21 Apr 2021; Published: 31 Jul 2021.

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Abstract

 

Latar Belakang : Hasil pengobatan skizofenia menunjukkan sebanyak 85% mengalami penurunan fungsi. Remisi klinis tidak selalu mengarah pada pemulihan fungsi. Defisiensi folat diidentifikasi sebagai salah satu faktor risiko skizofrenia.

Tujuan : Mengetahui manfaat ajuvan asam folat dalam memperbaiki fungsi personal dan sosial pasien skizofrenia kronis.

Metode : Penelitian eksperimental dengan desain double blind – randomized controlled trial, pre post test design. Semua subjek yang memenuhi kriteria inklusi diambil menurut waktu (consecutive sampling), kemudian secara blok random dikelompokkan dalam kelompok perlakuan dan kelompok kontrol. Perlakuan dengan ajuvan asam folat 2 mg / hari selama 4 minggu. Kelompok kontrol mendapatkan anti psikotik dengan plasebo. Anti psikotik yang digunakan tidak sama. PSP diukur sebelum dan sesudah perlakuan. Instrumen penelitian menggunakan kuesioner sosiodemografi dan kuesioner wawancara terstruktur Personal and Social Performance Scale versi Indonesia.

Hasil :  Terdapat 66 subjek yang memenuhi kriteria inklusi, 2 diantaranya Drop Out karena kejang dan SNM. Uji komparatif karakteristik demografik kelompok perlakuan dan kelompok kontrol tidak ada perbedaan bermakna. Terdapat peningkatan skor PSP yang bermakna secara statistik p <0,01 di kedua kelompok dengan peningkatan skor PSP kelompok perlakuan lebih tinggi (p = 0,029).

Simpulan : Ajuvan asam folat memperbaiki fungsi sosial dan personal pasien skizofrenia kronis.

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Keywords: Ajuvan asam folat; Fungsi sosial dan personal; Skizofrenia kronis.

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