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EFFECT OF PROBIOTIC AND PREBIOTIC CONSUMPTION ON BLOOD CHOLESTEROL LEVEL IN THE ELDERLY IN POSYANDU MANISJANGAN YOGYAKARTA

*Diyan Yunanto Setyaji orcid publons  -  Bachelor Nutrition Programme, Sekolah Tinggi Ilmu Kesehatan Panti Rapih, Indonesia
Fransisca Anjar Rina Setyani  -  Sekolah Tinggi Ilmu Kesehatan Panti Rapih, Indonesia
Received: 15 May 2021; Published: 31 Jul 2021.

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Abstract

Background: With advanced age, an increase in lipid profile is associated with the incidence of cardiovascular disease. Previous studies showed that the administration of probiotic and/or prebiotic are effective in improving lipid profiles. However, other studies have also shown that probiotic and prebiotic had insignificant effects on lipid profiles.

Objectives: Determined the effects of probiotic and prebiotic on blood cholesterol level in the elderly.

Methods: A total of 64 elderly who did not take cholesterol-lowering drugs enrolled in the quasi-experiment pretest-posttest design and were assigned to three interventions and control groups. The subjects in PRE-group consumed 100 grams of mung bean porridge per day; the subjects in PRO-group consumed 65 ml of fermented milk enriched with Lactobacillus casei Shirota strain per day; the subjects in PREPRO-group consumed 100 grams of mung bean porridge and 65 ml of fermented milk enriched with Lactobacillus casei Shirota strain per day. All intervention groups received treatment for 4 weeks. The control group did not receive any treatment during the study. Before and after treatment, cholesterol data was collected. Paired t-test, ANOVA, Post-hoc LSD were used for statistical analysis.

Results There was an increase in cholesterol levels in PRE, PRO, PREPRO-groups (12.93 mg/dL; 48.37 mg/dL; and 7.62 mg/dL). Among the three intervention groups, only the consumption of probiotic was significant for changes in blood cholesterol levels (p 0.023). The administration of various interventions did not have a significant effect on changes in cholesterol levels (p 0.246) when compared to the control group.

Conclusion: Prebiotic and probiotic do not lower blood cholesterol level in the elderly in Posyandu Manisjangan Yogyakarta.

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Keywords: Probiotic; Prebiotic; Cholesterol; Elderly

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  1. WHO. World health statistics 2018: Monitoring health for the SDGs, sustainable development goals. Geneva; World Health Organization 2018
  2. National Institute of Health Research Development (NIHRD). Laporan Nasional Riskesdas 2018. Jakarta; Lembaga Penerbit Badan Penelitian dan Pengembangan Kesehatan 2019
  3. Aguirre M, Bussolo de Souza C, Venema K. The gut microbiota from lean and obese subjects contribute differently to the fermentation of arabinogalactan and inulin. PLoS ONE 2016; 11(7): 1-18
  4. Fuentes MC, Lajo T, Carrion JM, et al Cholesterol-lowering efficacy of lactobacillus plantarum CECT 7527, 7528 and 7529 in hypercholesterolaemic adults. British Journal of Nutrition 2013; 109: 1866–1872
  5. Hove KD, Faerch K, Lund SS, et al. Effects of 12 weeks of treatment with fermented milk on blood pressure, glucose metabolism and markers of CVD risk in patients with type 2 diabetes: a randomised double-blind placebo-controlled study. European Journal of Endocrinology 2015; 172: 11-20
  6. Gibson GR, Scott KP, Rastall RA, et al. Dietary prebiotics: Current status and new definition. Food
  7. Science & Technology Bulletin: Functional Foods 2010: 7(1), 1–19
  8. Femia AP, Luceri C, Dolara P, et al. Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bififidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats. Carcinogenesis 2002; 23(11): 1953-60
  9. Aktimur SH, Suher M, Darilmaz DO, et al. Effects of probiotics, prebiotics and symbiotics on serum cholesterol levels. Clinic in Surgery 2017; 2(1652):1-3
  10. Panesar PS, Kumari S, Panesar R. Biotechnological approaches for the production of prebiotics and their potential applications. Crit. Rev. Biotechnol 2013; 33: 345–364
  11. Tan CX, Azrina A. Dietary fiber and total phenolic content of selected raw and cooked beans and its combinations. International Food Research Journal 2017; 24(5): 1863-1868
  12. Howard BV, Wylie-Rosett J. Sugar and Cardiovascular Disease. Circulation. 2002; 106: 523-527
  13. DiNicolantonio JJ, Lucan SC, O’Keefe JH. The evidence for saturated fat and for sugar related to coronary heart disease. Prog Cardiovasc Dis 2016; 58(5): 464–472
  14. de Roos NM, Schouten G, Katan MB. Yogurt enriched with Lactobacillus acidophilus does not lower blood lipids in healthy men and women with normal to borderline high serum cholesterol levels. European Journal of Clinical Nutrition 1999; 53: 277–280
  15. Naruszewicz M, Johansson ML, Zapolska-Downar D, et al. Effect of Lactobacillus plantarum 299v on cardiovascular disease risk factors in smokers. American Journal of Clinical Nutrition 2002;76: 1249–1255
  16. Xiao JZ, Kondo S, Takahashi S. Effects of milk products fermented by Bifidobacterium longum on blood lipids in rats and healthy adult male volunteers. Journal of Dairy Science 2003; 86:2452–2461
  17. Fabian E, Elmadfa I. Influence of daily consumption of probiotic and conventional yoghurt on the plasma lipid profile in young healthy women. Annals of Nutrition and Metabolism 2006; 50:387–393
  18. Simons LA, Armansec SG, Conway P, et al. Effect of Lactobacillus fermentum on serum lipids in subjects with elevated serum. Nutrition Metabolism and Cardiovascular Disease 2006; 16: 531–535
  19. Davani-Davari D, Negahdaripour M, Karimzadeh I, Seifan M, Mohkam M, Masoumi SJ, et al. Prebiotics: Defifinition, types, sources, mechanisms, and clinical applications. Foods 2019; 8: 92
  20. Delzenne NM, Kok N, Fiordaliso MF, et al. Dietary fructooligosaccharides modify lipid metabolism in rats. American Journal of Clinical Nutrition 1993; 57(5): 820S
  21. Félix-Redondo FJ, Grau M, Fernández-Bergés D. Cholesterol and cardiovascular disease in the elderly: Facts and gaps. Aging and Disease 2013; 4(3); 154-169
  22. Reiner Z, Catapano AL, De Backer G, Graham I, Taskinen MR, Wiklund et al. The task force for the management of dyslipidaemia of the European Society of Cardiology and the European Atherosclerosis Society. ESC/EAS Guidelines for the management of dyslipidaemia. Eur Heart J 2011; 32:1769-818
  23. Healy GN, Clark BK, Winkler EA, Gardiner PA, Brown WJ, Matthews CE. Measurement of adults’ sedentary time in population-based studies. Am J Prev Med 2011, 41:216-27

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