skip to main content

PERBEDAAN KADAR ASAM URAT PADA WANITA LANSIA DENGAN PERSEN LEMAK TUBUH OBESITAS DAN NON-OBESITAS

Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro, Indonesia

Received: 26 Nov 2019; Published: 26 Nov 2019.

Citation Format:
Abstract

Latar Belakang : Obesitas adalah suatu kelainan metabolisme, dimana terjadi ketidakseimbangan antara energi yang masuk dan energi yang keluar. Obesitas pada lansia merupakan salah satu masalah kesehatan paling serius didunia. Pada penderita obesitas, resiko untuk mengalami penyakit gout lebih tinggi. Penyakit gout lebih sering menyerang pada orang yang mengalami kelebihan berat badan lebih dari 30%. Penelitian ini bertujuan untuk mengetahui perbedaan kadar asam urat pada wanita lansia obesitas dan non obesitas.

Metode :Jenis penelitian ini adalah observasional dengan rancangan cross-sectional. Jumlah subjek penelitian adalah 56 orang wanita dengan usia 60-74 tahun. Kadar asam urat diperoleh menggunakan metode enzimatik, sedangkan status obesitas diperoleh menggunakan alat BIA (Bioelectrical Impedance Analyser).

Hasil :Kadar asam urat sebagian besar kadar asam urat subjek (78,6%) berada dalam rentang normal, yaitu antara 2,6 – 6 mg/dl, sementara 12 orang subjek (21,4%) mengalami hiperurisemia. Pada subjek obesitas  ditemukan 7 orang subjek hiperurisemia (> 6mg/dl), sedangkan pada subjek non obesitas ditemukan 5 orang subjek hiperurisemia ( 6mg/dl). Hasil statistik menunjukkan bahwa tidak terdapat perbedaan kadar asam urat antara subjek obesitas dan non obesitas (p>0,05).

Fulltext View|Download
Keywords: asam urat; obesitas; lansia

Article Metrics:

  1. Departemen Kesehatan RI. Pedoman Tatalaksana Gizi Usia Lanjut untuk Tenaga Kesehatan. Direktorat Bin Gizi Masyarakat Ditjen Binkesmas Depkes RI; 2003
  2. R. Boedhi Darmojo. Teori Proses Menua. In : R. Boedhi Drmojo, H. Hadi Martono, editros. Buku Ajar Geriatri (Ilmu Kesehatan Usia Lanjut) 3rd ed. Jakarta. Balai Penerbit FKUI; 2006.p. 3:13
  3. World Health Organization. Obesity and overweight. Fact sheet, 311. http://www.who.int/medi acentre/factsheets/fs311/en/index.html (accessed on 13/May/2011)
  4. Murray RK, Granner DK, Rodwell VW. Biokimia Harper Edisi 27(alih bahasa: dr. Brahm U. Pendit). Jakarta: Penerbit Buku Kedokteran EGC; 2006.P.317
  5. Tala H.I. Fakhouri, Ph.D., M.P.H.; Cynthia L. Ogden, Ph.D, et al. Prevalence of Obesity Among Older Adults in the United States, 2007–2010. NCHS Data Brief. 2012. 2-4
  6. Zamboni M, Mazzali G, Zoico E, et al. Health consequences of obesity in the elderly: a review of four unresolved questions. Int J Obes (Lond). 2005;29:1011–1029
  7. Gross LS, Li L, Ford ES, Liu S. Increased consumption of refined carbohydratesand the epidemic of type 2 diabetes in the United States: an ecologic assessment. Am J Clin Nutr. 2004;79:774-9
  8. Tsushima Y, Nishizawa H, Tochino Y, Nakatsuji H, Sekimoto R, Nagao H, et al. Uric acid secretion from adipose tissue and its increase in obesity. J Biol Chem. 2013;288:27138–49
  9. Viazzi F, Garneri D, Leoncini G, Gonnella A, Muiesan M.L, Ambrosioni E, et al. Serum Uric Acid and its relationship wity metabolic syndrome and cardiovascular risk profile in patients with hypertension: Insights from the I-DEMAND study. Nutirtion, Metabolisme & Cardiovascular Diseases
  10. Lin JD, Chiou WK, Chang HY, Liu FH, Weng HF. Serum uric acid and leptin levels in metabolic syndrome: a quandary over the role of uric acid. Metabolism 2007;56:751-6
  11. Chuang SY, Lee SC, Hsien YT. Trends in Hyperuricemia and Gout Prevalence: Nutrition and Health Survey in Taiwan from 1993-1996 to 2005-2008. Asia Pac Clin Nutr. 2011; 20(2): 301-8
  12. Darmawan J, Rasker JJ, Nuralim H. The Effect of Control and Self-Medication of Chronic Gout in a Developing Country
  13. Kim SY, Guevara JP, Kim KM, Choi HK, Heitjan DF, Albert DA: Hyperuricemia and risk of stroke: a systematic review and meta-analysis. Arthritis Rheum. 2009, 61:885-892
  14. Matsuura F, Yamashita S, Nakamura T, Nishida M, Nozaki S, Funahashi T, Matsuzawa Y. Effect of visceral fat accumulation on uric acid metabolism in male obese subjects: visceral fat obesity is linked more closely to overproduction of uric acid than subcutaneous fat obesity. Metabolism 1998;47:929-33
  15. Bonora E, Targher G, Zenere M.B, Saggiani F, Cacciatori V, Tosi, F, Travia D, Zenti MG, Branzi P, Santi L, Muggeo M. Relationship of uric acid concentration to cardiovascular risk factors in young men. Role of obesity and central fat distribution. The Verona Young Men Atherosclerosis Risk Factors Study. Int J Obes Relat Metab Disord 1996;20:975-80
  16. Oyama C, Takahashi T, Oyama M, Oyamada T, Ohno T, Mayashita M, et al. Serum uric acid as an obesity telated indicator in early adolescence. Tohoku J. Exp. Med. 2006;209:257–262
  17. Fauzia YFH. Hubungan indeks masa tubuh dan usia dengan kadar asam urat pada remaja pra-obese dan obese di Purwokerto [Skripsi]. Purwokerto: Universitas Jendral Soedirman; 2013
  18. Bedir A, Topbas M, Tanyeri F, Alvur M, Arik N. Leptin might be a regulator of serum uric acid concentration in human. Jpn Heart J 2003;44:527-36
  19. Fruehwald-Schultes B, Peters A, Kern W, Beyer J, Pfutzner A. Serum leptin is associated with serum uric acid concentrations in humans. Metabolism 1999;48
  20. M. Jin, F. Yang, I. Yang, et al., Regulation of Uric Acid Metabolism and Excretion, Int J Cardiol. 2005. http://dx.doi.org/10.1016/j.ijcard.2015.08.109
  21. Murray RK, Granner DK, Mayes PA, Rowell VW, Biokimi Harper. Edisi 27th edition. Singapore; McGraw Hill; 2006.p. 184,301-309
  22. Chooi HK, Mount DB, Reginato AM. Patogenesis of Gout. Annals of Internal Medicine. Available at: http://www.internal-medicine.com By on August 16; 2008;143,7:499-516
  23. Milward DJ, Fereday A, Gibson N, Pacy PJ: Aging protein requirements, and protein turnover. Amer J Clin Nutr 66:1997.p.774–786
  24. Hernández EÁ, Kahl S, Seelig A, Begovatz P, Irmler M, Kupriyanova Y, et al. Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance. 2017;127(2):695–708. 37
  25. Tsushima Y, Nishizawa H, Nakatsuji H, Nagao H, Kato K, Imaizumi K, et al. Uric Acid Secretion from Adipose Tissue and Its Increase in Obesity. 2013
  26. WHO 2004. Tanita Corporation of America Inc. 2625 S. Clearbrook Drive Arlington Heights II 60005

Last update:

No citation recorded.

Last update:

No citation recorded.