DOI: https://doi.org/10.14710/jnc.v9i1.24266

PENGARUH PEMBERIAN TEPUNG SORGUM (Sorghum bicolor L. Moench) TERHADAP KADAR GLUKOSA DARAH PUASA TIKUS DIABETES

Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro, Indonesia

Received: 28 Jul 2019; Published: 25 Apr 2020.

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Abstract

Latar Belakang : Diabetes adalah kelainan endokrin yang ditandai dengan hiperglikemi akibat resistensi insulin. Tepung sorgum memiliki indeks glikemik yang tergolong rendah dan kandungan serat yang tinggi sehingga dapat menurunkan kadar glukosa darah puasa dan meningkatkan sensitivitas insulin.

Tujuan: Mengetahui perbedaan pemberian tepung sorgum terhadap kadar glukosa darah puasa pada tikus diabetes.

Metode : Penelitian true experimental dengan desain pretest-posttest randomized control group. Sebanyak 18 ekor tikus wistar jantan dibagi menjadi 3 kelompok meliputi kelompok kontrol negatif (K -), kontrol positif (K +) dan perlakuan (P). Kelompok K – dan K + diberi pakan standar sebanyak 20 g/hari, sedangkan P diberi pakan yang terdiri dari tepung sorgum 5 g/hari dan pakan standar sebanyak 15 g/hari selama 28 hari. Kadar glukosa darah diukur dengan metode GOD – PAP menggunakan spektrofotometer. Data yang terkumpul dianalisis secara statistik menggunakan uji Paired t – Test, uji One Way Anova, dan uji Kruskal Wallis.

Hasil: Terdapat perbedaan signifikan kadar glukosa darah puasa antar kelompok sebelum (p=0,000) dan sesudah (p=0,000) pemberian perlakuan Selisih penurunan kadar glukosa darah puasa pada kelompok P sebanyak 150,63± 2,57 mg/dl (p=0,000).

Simpulan : Tepung sorgum dapat menurunkan kadar glukosa darah puasa tikus diabetes secara signifikan.

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Keywords: Tepung sorgum; diabetes; kadar glukosa darah puasa

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