DOI: https://doi.org/10.14710/dmj.v14i3.47640

POTENTIAL OF MIRNA-183, MIRNA-29B, AND MIRNA-34A COMBINATION AS A NOVEL ADVANCED SENSORINEURAL HEARING LOSS DIAGNOSTIC AND THERAPEUTIC (THERAGNOSTIC) AGENT

*Agyta Hanifa Faiza orcid  -  Undergraduate Program, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia, Indonesia
Gabriela Valencia Putri Husodho orcid  -  Faculty of Medicine, Universitas Diponegoro, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia, Indonesia
Anatalya Diah Ayu Kumalasari orcid  -  Undergraduate Program, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia, Indonesia

Citation Format:
Abstract

Background: Sensorineural hearing loss (SNHL) is a hearing disability that makes up 90% of all hearing loss in general. This condition reduces quality of life and causes lifelong disability. Current diagnostic and therapeutic agents are considered less than optimal and need to be developed further. MicroRNAs (miRNAs), such as miRNA-34a, miRNA-29b, and miRNA-183, play a role in the pathogenesis of SNHL and thus have potential as specific biomarkers and therapeutic agents. Objective: To open a new perspective regarding the use of diagnostic biomarkers and miRNA therapy as a new step towards the era of personalized medicine in SNHL patients. Methods: This literature review used a non-systematic review method using the search engines PubMed, Science Direct, and ProQuest. Results: Increased expression of miRNA-34a, miRNA-29b, and miRNA-183 causes a decrease in the number of inner hair cells hence causing hearing loss. This means that these miRNAs can be used as biomarkers in the diagnosis of SNHL. Suppression of these miRNAs to certain levels could potentially be a therapy for SNHL, as it showed reduced oxidative stress and apoptosis. Suppression of miRNA-29b expression causes increased proliferation and reduced oxidative stress. However, knock out of miRNA-183 shows disruption in stereociliary bundle development and hair cell maturation hence when using miRNA inhibitors as therapy it is important to take note of dosage. Conclusion: miRNA-34a, miRNA-29b, and miRNA-183 have potential as diagnostic biomarkers and therapeutic agents for SNHL by regulating levels of oxidative stress, apoptosis, and the number of inner hair cells. Utilizing these three miRNAs simultaneously can increase the specificity, sensitivity and effectiveness in the diagnosis and therapy of SNHL.

Fulltext View|Download
Keywords: miRNA-183; miRNA-29b; miRNA-34a; SNHL; Theragnostic

Article Metrics:

Article Info
Section: Original Articles
Language : EN
Recent articles
CORRELATION OF NEUTROPHIL-LYMPHOCYTE AND PLATELET-LYMPHOCYTE RATIOS WITH IN-HOSPITAL MORTALITY IN PATIENT ACUTE DECOMPENSATED HEART FAILURE POTENTIAL OF MIRNA-183, MIRNA-29B, AND MIRNA-34A COMBINATION AS A NOVEL ADVANCED SENSORINEURAL HEARING LOSS DIAGNOSTIC AND THERAPEUTIC (THERAGNOSTIC) AGENT CORRELATION BETWEEN LIVER TRANSAMINASE ENZYME AND LEUKOCYTE COUNT IN TUBERCULOSIS PATIENTS WHO RECEIVED ANTI-TUBERCULOSIS DRUG THERAPY TUMOR OF THE LOWER JAW IN PEDIATRIC PATIENT WITH DEVELOPMENTAL DELAY: A CASE REPORT AND LITERATURE REVIEW COMPARISON OF THE IMPLEMENTATION OF AROMATHERAPY OF PAPPERMINT with HAND MASSAGE ON THE PAIN OF PATIENTS AFTER CHOLELITHIASIS SURGERY : A CASE STUDY MEIGS SYNDROME MIMICKING MALIGNANCY: A DIAGNOSIS CHALLENGE More recent articles
  1. Deafness and Hearing Loss [Internet]. [cited 2024 Jul 14]. Available from: https://www.who.int/news-room/fact-sheets/detail/deafness-and-hearing-loss
  2. Tanna RJ, Lin JW, De Jesus O. Sensorineural Hearing Loss. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 [cited 2024 Jul 14]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK565860/
  3. Lye J, Delaney DS, Leith FK, Sardesai VS, McLenachan S, Chen FK, et al. Recent Therapeutic Progress and Future Perspectives for the Treatment of Hearing Loss. Biomedicines. 2023 Dec 18;11(12):3347
  4. Ding L, Wang J. MiR-106a Facilitates The Sensorineural Hearing Loss Induced by Oxidative Stress by Targeting Connexin-43. Bioengineered. 2022 Jun 1;13(6):14080–93
  5. Chen HHR, Wijesinghe P, Nunez DA. MicroRNAs in Acquired Sensorineural Hearing Loss. J Laryngol Otol. 2019 Aug;133(8):650–7
  6. Wang H, Lin H, Kang W, Huang L, Gong S, Zhang T, et al. miR-34a/DRP-1-mediated Mitophagy Participated in Cisplatin-Induced Ototoxicity Via Increasing Oxidative Stress. BMC Pharmacology and Toxicology. 2023;24(1)
  7. Xue T, Wei L, Zha DJ, Qiu JH, Chen FQ, Qiao L, et al. miR-29b Overexpression Induces Cochlear Hair Cell Apoptosis Through The Regulation of SIRT1/PGC-1α Signaling: Implications for Age-Related Hearing Loss. Int J Mol Med. 2016 Nov;38(5):1387–94
  8. Ha SM, Hwang KR, Park IH, Park S, Choi JS, Park DJ, et al. Circulating Micrornas as Potentially New Diagnostic Biomarkers of Idiopathic Sudden Sensorineural Hearing Loss. Acta Oto-Laryngologica. 2020 Dec 1;140(12):1013–20
  9. Wagner EL, Shin JB. Mechanisms of Hair Cell Damage and Repair. Trends Neurosci. 2019 Jun;42(6):414–24
  10. Ranganathan K, Sivasankar V. MicroRNAs - Biology and Clinical applications. J Oral Maxillofac Pathol. 2014;18(2):229–34
  11. Lu TX, Rothenberg ME. MicroRNA. J Allergy Clin Immunol. 2018 Apr;141(4):1202–7
  12. Ho PTB, Clark IM, Le LTT. MicroRNA-Based Diagnosis and Therapy. Int J Mol Sci. 2022 Jun 28;23(13):7167
  13. Wang L, Xie Y, Chen W, Zhang Y, Zeng Y. miR-34a Regulates Lipid Droplet Deposition in 3T3-L1 and C2C12 Cells by Targeting LEF1. Cells. 2023 Jan;12(1):167
  14. Piletič K, Kunej T. MicroRNA Epigenetic Signatures in Human Disease. Arch Toxicol. 2016 Oct;90(10):2405–19
  15. Pang J, Xiong H, Yang H, Ou Y, Xu Y, Huang Q, et al. Circulating miR-34a Levels Correlate With Age-Related Hearing Loss in Mice and Humans. Experimental Gerontology. 2016 Apr 1;76:58–67
  16. Xiong H, Chen S, Lai L, Yang H, Xu Y, Pang J, et al. Modulation of Mir-34a/SIRT1 Signaling Protects Cochlear Hair Cells Against Oxidative Stress And Delays Age-Related Hearing Loss Through Coordinated Regulation of Mitophagy and Mitochondrial Biogenesis. Neurobiology of Aging. 2019 Jul;79:30–42
  17. Xiong H, Pang J, Yang H, Dai M, Liu Y, Ou Y, et al. Activation of miR-34a/SIRT1/p53 Signaling Contributes To Cochlear Hair Cell Apoptosis: Implications for Age-Related Hearing Loss. Neurobiology of Aging. 2015 Apr;36(4):1692–701
  18. Pang J, Xiong H, Lin P, Lai L, Yang H, Liu Y, et al. Activation Of Mir-34a Impairs Autophagic Flux and Promotes Cochlear Cell Death Via Repressing ATG9A: Implications for Age-Related Hearing Loss. Cell Death Dis. 2017 Oct;8(10):e3079
  19. Lin Y, Shen J, Li D, Ming J, Liu X, Zhang N, et al. Mir-34a Contributes to Diabetes-Related Cochlear Hair Cell Apoptosis Via SIRT1/HIF-1α Signaling. General and Comparative Endocrinology. 2017 May 15;246:63–70
  20. Ebada MA, Mostafa A, Gadallah AHA, Alkanj S, Alghamdi BS, Ashraf GM, et al. Potential Regulation of miRNA-29 and miRNA-9 by Estrogens in Neurodegenerative Disorders: An Insightful Perspective. Brain Sciences. 2023 Feb;13(2):243
  21. Hao S, Wang L, Zhao K, Zhu X, Ye F. Rs1894720 Polymorphism in MIAT Increased Susceptibility to Age‐Related Hearing Loss by Modulating The Activation of Mir‐29b/SIRT1/PGC‐1α Signaling. J of Cellular Biochemistry. 2019 Apr;120(4):4975–86
  22. Ichiyama K, Dong C. The Role of Mir-183 Cluster in Immunity. Cancer Letters. 2019 Feb 28;443:108–14
  23. Li S, Meng W, Guo Z, Liu M, He Y, Li Y, et al. The miR-183 Cluster: Biogenesis, Functions, and Cell Communication via Exosomes in Cancer. Cells. 2023 May 5;12(9):1315
  24. Amini-Farsani Z, Asgharzade S. The Impact of Mir-183/182/96 Gene Regulation on The Maturation, Survival, and Function of Photoreceptor Cells In The Retina. Journal of Comparative Neurology. 2020;528(9):1616–25
  25. Farnoosh G, Mahmoudian-Sani MR. Effects of Growth Factors and the MicroRNA-183 Family on Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells Towards Auditory Neuron-Like Cells. Stem Cells Cloning. 2020 Sep 10;13:79–89
  26. Lee SH, Ju HM, Choi JS, Ahn Y, Lee S, Seo YJ. Circulating Serum miRNA-205 as a Diagnostic Biomarker for Ototoxicity in Mice Treated with Aminoglycoside Antibiotics. Int J Mol Sci. 2018 Sep 19;19(9):2836
  27. Geng R, Furness DN, Muraleedharan CK, Zhang J, Dabdoub A, Lin V, et al. The microRNA-183/96/182 Cluster is Essential for Stereociliary Bundle Formation and Function of Cochlear Sensory Hair Cells. Sci Rep. 2018 Dec 21;8(1):18022
  28. Momin MY, Gaddam RR, Kravitz M, Gupta A, Vikram A. The Challenges and Opportunities in the Development of MicroRNA Therapeutics: A Multidisciplinary Viewpoint. Cells. 2021 Nov 9;10(11):3097
  29. Abd-Aziz N, Kamaruzman NI, Poh CL. Development of MicroRNAs as Potential Therapeutics against Cancer. J Oncol. 2020 Jul 15;2020:8029721
  30. Zhang S, Cheng Z, Wang Y, Han T. The Risks of miRNA Therapeutics: In a Drug Target Perspective. Drug Des Devel Ther. 2021 Feb 22;15:721–33
  31. Chen L, Heikkinen L, Wang C, Yang Y, Sun H, Wong G. Trends in The Development of Mirna Bioinformatics Tools. Brief Bioinform. 2019 Jun 17;20(5):1836–52
  32. Larkey NE, Brucks CN, Lansing SS, Le SD, Smith NM, Tran V, et al. Molecular Structure and Thermodynamic Predictions To Create Highly Sensitive Microrna Biosensors. Analytica Chimica Acta. 2016 Feb 25;909:109–20
  33. Lin Y, Wei Y, Wei Y, Yu H, Zhang W, Li C, et al. Dexmedetomidine Alleviates Oxidative Stress and Mitochondrial Dysfunction in Diabetic Peripheral Neuropathy Via The microRNA-34a/SIRT2/S1PR1 Axis. International Immunopharmacology. 2023 Apr;117:109910

Last update:

No citation recorded.

Last update:

No citation recorded.