skip to main content

MEIGS SYNDROME MIMICKING MALIGNANCY: A DIAGNOSIS CHALLENGE

*Ratri Wulandari orcid scopus  -  Department of Obstetrics and Gynaecology, Indonesia
Yosi Tamara  -  Universitas Gadjah Mada Academic Hospital, Indonesia, Indonesia

Citation Format:
Abstract

Background: Meigs syndrome is a benign ovarian mass associated with pleural effusion and ascites. The ovarian tumor is typically a fibroma, the most common benign pure stromal tumor, with 10-15% of cases presenting with pleural effusion or ascites. Case Presentation: Here, we present a Meigs syndrome in a 57-year-old woman. This patient complained of an abdominal mass and massive pleural effusion. Multiple uterine myomas and left ovarian solid tumor were found during laparotomy. Following the removal of ovarian mass, the patient’s condition improved, and she was discharged a week after being hospitalized. Conclusion: The clinical symptoms of Meigs syndrome are similar to those of malignant disease. However, with optimal treatment, the outcome of Meigs’s syndrome is generally satisfactory. 

Fulltext View|Download
Keywords: Ascites, fibroma, Meigs syndrome, ovarian tumors, pleural effusion
Funding: -

Article Metrics:

  1. Mohammed SA, Kumar A. Meigs Syndrome. StatPearls [Internet]. 2022 Jul 14 [cited 2023 Mar 1]; Available from: https://www.ncbi.nlm.nih.gov/books/NBK559322/
  2. Miyoshi A, Miyatake T, Hara T, Tanaka A, Komura N, Komiya S, et al. Etiology of Ascites and Pleural Effusion Associated with Ovarian Tumors: Literature Review and Case Reports of Three Ovarian Tumors Presenting with Massive Ascites, but without Peritoneal Dissemination. Case Rep Obstet Gynecol. 2015;2015:1–5
  3. Shih JA, Garrett LA, Carbo AR. Meigs’ Syndrome: A Sheep in Wolf’s Clothing. American Journal of Medicine [Internet]. 2019 Nov 1 [cited 2023 Mar 1];132(11):e803–4. Available from: http://www.amjmed.com/article/S0002934319304450/fulltext
  4. Riker D, Goba D. Ovarian mass, pleural effusion, and ascites revisiting meigs syndrome. J Bronchology Interv Pulmonol [Internet]. 2013 Jan [cited 2023 May 23];20(1):48–51. Available from: https://journals.lww.com/bronchology/Fulltext/2013/01000/Ovarian_Mass,_Pleural_Effusion,_and_Ascites_.15.aspx
  5. Abdelazim I, Abu-Faza M, Abdelrazek K, Amer O, Shikanova S, Zhurabekova G. Ovarian Fibroma Commonly Misdiagnosed as Uterine Leiomyoma. Gynecol Minim Invasive Ther [Internet]. 2020 Jan 1 [cited 2023 May 23];9(1):36. Available from: /pmc/articles/PMC7008642/
  6. Krenke R, Maskey-Warzechowska M, Korczynski P, Zielinska-Krawczyk M, Klimiuk J, Chazan R, et al. Pleural Effusion in Meigs’ Syndrome—Transudate or Exudate?: Systematic Review of the Literature. Medicine [Internet]. 2015 [cited 2023 May 24];94(49). Available from: /pmc/articles/PMC5008483/
  7. Musleh JKM, Almulhem M, Al Qahtani NH. Case Report: Massive ascites, pelvic mass, elevated CA-125 and weight loss: think outside the ‘ovaries’. BMJ Case Rep [Internet]. 2017 [cited 2023 May 24];2017. Available from: /pmc/articles/PMC5612005/
  8. Kortekaas KE, Pelikan HMP. Hydrothorax, ascites and an abdominal mass: not always signs of a malignancy - Three cases of Meigs’ syndrome. J Radiol Case Rep [Internet]. 2018 Jan 1 [cited 2023 May 24];12(1):17. Available from: /pmc/articles/PMC5965394/
  9. Benjapibal M, Sangkarat S, Laiwejpithaya S, Viriyapak B, Chaopotong P, Jaishuen A. Meigs’ Syndrome with Elevated Serum CA125: Case Report and Review of the Literature. Case Rep Oncol [Internet]. 2009 Apr 1 [cited 2023 May 25];2(1):61–6. Available from: https://karger.com/cro/article/2/1/61/88030/Meigs-Syndrome-with-Elevated-Serum-CA125-Case
  10. Yazdani S, Alijanpoor A, Sharbatdaran M, Bouzari Z, Samakosh MA, Lakaieandi F, et al. Meigs’ syndrome with elevated serum CA125 in a case of ovarian fibroma /thecoma. Caspian J Intern Med [Internet]. 2014 [cited 2023 May 25];5(1):43. Available from: /pmc/articles/PMC3894471/
  11. Morán-Mendoza A, Alvarado-Luna G, Calderillo-Ruiz G, Serrano-Olvera A, LÓPEZ-GRANIEL CM, Gallardo-Rincón D. Elevated CA125 level associated with Meigs’ syndrome: case report and review of the literature. International Journal of Gynecologic Cancer [Internet]. 2006 Jan 1 [cited 2023 May 25];16(Suppl 1):315–8. Available from: https://ijgc.bmj.com/content/16/Suppl_1/315
  12. Duffy MJ. Tumor Markers in Clinical Practice: A Review Focusing on Common Solid Cancers. Medical Principles and Practice [Internet]. 2012 Dec 1 [cited 2023 May 26];22(1):4–11. Available from: https://karger.com/mpp/article/22/1/4/203271/Tumor-Markers-in-Clinical-Practice-A-Review
  13. Belczacka I, Latosinska A, Metzger J, Marx D, Vlahou A, Mischak H, et al. Proteomics biomarkers for solid tumors: Current status and future prospects. Mass Spectrom Rev [Internet]. 2019 Jan 1 [cited 2023 May 26];38(1):49–78. Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/mas.21572
  14. Saha S, Robertson M. Meigs’ and Pseudo-Meigs’ syndrome. Australas J Ultrasound Med [Internet]. 2012 Feb 1 [cited 2023 May 25];15(1):29–31. Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/j.2205-0140.2012.tb00140.x
  15. Murayama Y, Kamoi Y, Yamamoto H, Isogai J, Tanaka T. Meigs’ syndrome mimicking heart failure with preserved ejection fraction: a case report. BMC Cardiovasc Disord [Internet]. 2020 Oct 7 [cited 2023 May 25];20(1). Available from: /pmc/articles/PMC7542734/
  16. Aziz S, Hanaa L, Noha A, Najia Z, Amina L, Aicha K, et al. Meigs syndrome: About an uncommon case report. Clinical Journal of Obstetrics and Gynecology. 2023 Jan 6;6(1):010–3
  17. Nunes N, Ambler G, Foo X, Naftalin J, Widschwendter M, Jurkovic D. Use of IOTA simple rules for diagnosis of ovarian cancer: meta-analysis. Ultrasound in Obstetrics & Gynecology [Internet]. 2014 Nov 1 [cited 2023 May 25];44(5):503–14. Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/uog.13437
  18. Bouab M, Touimi AB, El Omri H, Boufettal H, Mahdaoui S, Samouh N. Primary ovarian fibroma in a postmenopausal woman: A case report. Int J Surg Case Rep. 2022 Mar 1;92:106842

Last update:

No citation recorded.

Last update:

No citation recorded.