DOI: https://doi.org/10.14710/dmj.v13i6.47012

The Correlation between Sleep Quality and Acne vulgaris Incidence in Medical Students of Universitas Tarumanagara

Helena Ivonne Cungse Adinegoro  -  Faculty of Medicine, Universitas Tarumanagara, Letjen S. Parman St No.1, RT.6/RW.16, Tomang, Grogol petamburan, West Jakarta City, Jakarta 11440, Indonesia
*Donatila Mano  -  Department of Microbiology, Universitas Tarumanagara, Jakarta, Indonesia, Indonesia

Citation Format:
Abstract

Background: Acne vulgaris is still occurred among medical students worldwide, with a prevalence range of 34,38% to 97,9%. Acne vulgaris, which affects the pilosebaceous unit, is suspected to be related to sleep quality because it involves many hormones, including melatonin, which is associated to sleep. Melatonin can suppress androgens, which play a crucial role in Acne vulgaris pathogenesis. Besides, some studies said that melatonin has a role to suppress inflammation. Medical students also often experience poor sleep quality. Previous studies on the correlation between sleep quality and Acne vulgaris have shown varied results. Objective: This research was conducted to confirm the correlation between sleep quality and Acne vulgaris. Methods: A total of 195 medical students from Tarumanagara University classes of 2021 and 2022 participated in this study by answering the Pittsburgh Sleep Quality Index (PSQI) and Acne vulgaris questionnaires. Samples were taken using non-random consecutive sampling. This research used an analytical observational method with a cross-sectional design. Results: The study found that 92 respondents (47,2%) had good sleep quality, while 103 respondents had poor sleep quality (52,8%). A total of 123 respondents (63,15) experiences Acne vulgaris. Chi-square statistical analysis using SPSS software showed a significant correlation between sleep quality and Acne vulgaris (p-value <0,05; PRR = 1,261; 95% CI = 1,261-1,576). Conclusion: Poor sleep quality can increase the risk of developing Acne vulgaris.

Note: This article has supplementary file(s).

Fulltext View|Download |  Research Instrument
Research Instruments
Subject PSQI, Acne vulgaris
Type Research Instrument
  Download (264KB)    Indexing metadata
Keywords: Acne vulgaris; Melatonin Hormone; PSQI; Sleep Quality

Article Metrics:

Article Info
Section: Original Articles
Language : EN
Recent articles
The Association Between Hypertension and Stroke in PKU Muhammadiyah Gamping Hospital The Correlation between Sleep Quality and Acne vulgaris Incidence in Medical Students of Universitas Tarumanagara Effect of Giving Pineapple Juice (Ananas comosus) on The Viability of Wistar Rat Spermatozoa Those Exposed to Cigarette Smoke A 31-Year-Old Female with Inferior Paraparesis Upper Motor Neuron Type due to Destruction of Thoracic 6-7 Vertebrae due to Tuberculous Spondylitis : A Case Report Characteristics of Intracerebral Hemorrhage at Dr. Kariadi General Hospital: A Serial Case Multiple Decubitus Ulcers in Dm type II Patients with Autologous Plasma-Rich Platelet therapy : A Case Report More recent articles
  1. Dorland WAN. Dorland’s illustrated medical dictionary. 33rd ed. Philadelphia, PA: Elsevier; 2019
  2. Sembulingam K, Sembulingam P. Physiology of sleep. In: Essentials of medical physiology. 6th ed. India: Jayvee Brothers Medical Publishers (P) Ltd.; 2012
  3. CDC. How Much Sleep Do I Need? [Internet]. Centers for Disease Control and Prevention. 2022 [cited 2023 Sep 27]. Available from: https://www.cdc.gov/sleep/about_sleep/how_much_sleep.html
  4. National Sleep Foundation. How Much Sleep Do You Really Need? [Internet]. National Sleep Foundation. 2020 [cited 2023 Sep 27]. Available from: https://www.thensf.org/how-many-hours-of-sleep-do-you-really-need/
  5. Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Research. 1989;28(2):193–213. https:/doi.org/10.1016/0165-1781(89)90047-4
  6. Nelson KL, Davis JE, Corbett CF. Sleep quality: An evolutionary concept analysis. Nursing Forum. 2022;57(1):144–51. https://doi.org/10.1111/nuf.12659
  7. Rao WW, Li W, Qi H, Hong L, Chen C, Li CY, et al. Sleep quality in medical students: a comprehensive meta-analysis of observational studies. Sleep and Breathing. 2020;24(3):1151–65. https://doi.org/10.1007/s11325-020-02020-5
  8. Kang S, Amagai M, Bruckner AL, Enk AH, Margolis DJ, McMichael AJ, et al. Acne Vulgaris. In: Fitzpatrick’s dermatology. 9th ed. New York: McGraw-Hill Education; 2019. 1391–418 p
  9. The Institute for Health Metrics and Evaluation. Acne vulgaris — Level 3 cause [Internet]. 2019 [cited 2023 Sep 16]. Available from: https://www.healthdata.org/results/gbd_summaries/2019/acne-vulgaris-level-3-cause
  10. Sachdeva M, Tan J, Lim J, Kim M, Nadeem I, Bismil R. The prevalence, risk factors, and psychosocial impacts of acne vulgaris in medical students: A literature review. International journal of dermatology. 2021;60(7):792-798. https://doi.org/10.1111/ijd.15280
  11. Morshed ASM, Noor T, Uddin Ahmed MA, Mili FS, Ikram S, Rahman M, et al. Understanding the impact of acne vulgaris and associated psychological distress on self-esteem and quality of life via regression modeling with CADI, DLQI, and WHOQoL. Scientific Reports. 2023;13(1):21084. https://doi.org/10.1038/s41598-023-48182-6
  12. Elsaie ML. Hormonal treatment of acne vulgaris: An update. Clinical, Cosmetic and Investigational Dermatology. 2016; 9:241–8. https://doi.org/10.2147/CCID.S114830
  13. Yu K, Wang RX, Li MH, Sun TC, Zhou YW, Li YY, et al. Melatonin reduces androgen production and upregulates heme oxygenase-1 expression in granulosa cells from PCOS patients with hypoestrogenia and hyperandrogenia. Oxidative medicine and cellular longevity. 2019;2019(1). https://doi.org/10.1155/2019/8218650
  14. Tan DX, Reiter RJ, Zimmerman S, Hardeland R. Melatonin: Both a messenger of darkness and a participant in the cellular actions of non-visible solar radiation of near infrared light. Biology. 2023;12(1):89. https://doi.org/10.3390/biology12010089
  15. Sherwood L. Human physiology from cells to systems. 9th ed. Boston, MA: Cengage Learning; 2016
  16. Annisa F, Sulistiasari R. Hubungan antara kualitas tidur dengan terjadinya Acne vulgaris pada pasien di praktek dr. Nur afni, M. Biomed Medan 2020. Jurnal Kedokteran Ibnu Nafis. 2021;10(1):49–52. https://doi.org/10.30743/jkin.v10i1.145
  17. Silvia E, Febriyani A, Nando R, Riza A. Hubungan antara kualitas tidur dengan Acne vulgaris pada mahasiswa Fakultas Kedokteran Umum Universitas Malahayati angkatan 2019. Jurnal Medika Malahayati. 2020;4(1):33–8. https://doi.org/10.33024/jmm.v4i1.2464
  18. Primawati I, Ningsih LA, Ma’arif M. Relationship between sleep quality and incidence of Acne vulgaris in students of the faculty of medicine, Baiturrahmah University batch of 2020. Science Midwifery. 2022;10(4):2754–9. https://doi.org/10.35335/midwifery.v10i4.711
  19. Qin F, Zhang J, Zan L, Guo W, Wang J, Chen L, et al. Inhibitory effect of melatonin on testosterone synthesis is mediated via GATA-4/SF-1 transcription factors. Reproductive Biomedicine Online. 2015;31(5):638–46. https://doi.org/10.1016/j.rbmo.2015.07.009
  20. Tarocco A, Caroccia N, Morciano G, Wieckowski MR, Ancora G, Garani G, et al. Melatonin as a master regulator of cell death and inflammation: Molecular mechanisms and clinical implications for newborn care. Cell Death & Disease. 2019;10(4):317. https://doi.org/10.1038/s41419-019-1556-7
  21. Rusanova I, Martínez-Ruiz L, Florido J, Rodríguez-Santana C, Guerra-Librero A, Acuña-Castroviejo D, et al. Protective Effects of Melatonin on the Skin: Future Perspectives. International Journal of Molecular Sciences. 2019;20(19). https://doi.org/10.3390/ijms20194948
  22. Yu K, Deng SL, Sun TC, Li YY, Liu YX. Melatonin regulates the synthesis of steroid hormones on male reproduction: A Review. Molecules. 2018;23(2):447. https://doi.org/10.3390/molecules23020447
  23. Menaldi SLS, Bramono K, Indriatmi W. Ilmu penyakit kulit dan kelamin. 7th ed. Jakarta: FKUI; 2019
  24. Ribeiro B de M, Maurí L, Almeida cio C, Costa A, Francesconi F, Follador I, et al. Etiopathogeny of acne vulgaris: A practical review for day-to-day dermatologic practice. Surgical & Cosmetic Dermatology. 2015;7(33):20–6. https://doi.org/10.5935/scd1984-8773.2015731682
  25. Aryani IA, Antonius CS, Nugroho SA, Nopriyanti. Role of androgen on physiological function of pilosebaceous unit. Bioscientia Medicina: Journal of Biomedicine and Translational Research. 2021;5(6):545–51. https://doi.org/10.32539/bsm.v5i6.321
  26. Firlej E, Kowalska W, Szymaszek K, Roliński J, Bartosińska J. The role of skin immune system in acne. Journal of Clinical Medicine. 2022;11(6):1579. https://doi.org/10.3390/jcm11061579
  27. Yaşar NF, Badak B, Canik A, Baş SŞ, Uslu S, Öner S, et al. Effects of sleep quality on melatonin levels and inflammatory response after major abdominal surgery in an intensive care unit. Molecules. 2017;22(9):1537. https://doi.org/10.3390/molecules22091537
  28. Cho JH, Bhutani S, Kim CH, Irwin MR. Anti-inflammatory effects of melatonin: A systematic review and meta-analysis of clinical trials. Brain, Behavior, and Immunity. 2021; 93:245–53. https://doi.org/10.1016/j.bbi.2021.01.034
  29. Chen SJ, Huang SH, Chen JW, Wang KC, Yang YR, Liu PF, et al. Melatonin enhances interleukin-10 expression and suppresses chemotaxis to inhibit inflammation in situ and reduce the severity of experimental autoimmune encephalomyelitis. International Immunopharmacology. 2016; 31:169–77. https://doi.org/10.1016/j.intimp.2015.12.020

Last update:

No citation recorded.

Last update:

No citation recorded.