DOI: https://doi.org/10.14710/dmj.v13i3.45004

Correlation between Degree of Leprosy Disability and Serum IL-6 Levels in Patients with Leprosy Reactions: An Observational Study at the Donorojo Jepara Leprosy Hospital Center

*Syifa Nurisma Putri  -  Department of Biomedicine, Faculty of Medicine, Diponegoro University, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia
Farmaditya Eka Putra Mundhofir orcid scopus  -  Department of Histology, Diponegoro University, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia
Renni Yuniati orcid scopus  -  Department of Dermatology and Venereology, Diponegoro University, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia
Noor Wijayahadi scopus  -  Department of Pharmacology, Diponegoro University, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia
Yora Nindita orcid scopus  -  Department of Pharmacology, Diponegoro University, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia

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Abstract

Background: Leprosy is an infectious disease caused by Mycobacterium leprae bacteria which is still the focus of a global problem and causes disability in patients. The degree of disability in leprosy is assessed as mild and severe as a result of the inflammatory process. This study aims to determine the relationship between the degree of disability in leprosy and IL-6 serum levels as an inflammatory biomarker in leprosy patients. Methods: A Cross-sectional observational analytical study on leprosy patients aged 20-60 years, not pregnant, and undergoing treatment at Donorojo Jepara Hospital from March to April 2024. Serum IL-6 levels were analyzed using the ELISA method and tested for correlation with the degree of disability leprosy. Results: Statistical analysis of Spearman's correlation rank test shows a p value = 0.279 and the results of the line pattern on the Scatter dot graph are not linear. Conclusion: There is no correlation between serum IL-6 levels and the degree of disability in leprosy patients at Donorojo Jepara Hospital.

Keywords: Degree of Disability in Leprosy, Leprosy, Serum IL-6

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Keywords: Degree of Disability in Leprosy; Leprosy; Serum IL-6

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Section: Original Articles
Language : EN
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