DOI: https://doi.org/10.14710/dmj.v13i3.45004

Correlation between Degree of Leprosy Disability and Serum IL-6 Levels in Patients with Leprosy Reactions: An Observational Study at the Donorojo Jepara Leprosy Hospital Center

*Syifa Nurisma Putri  -  Department of Biomedicine, Faculty of Medicine, Diponegoro University, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia
Farmaditya Eka Putra Mundhofir orcid scopus  -  Department of Histology, Diponegoro University, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia
Renni Yuniati orcid scopus  -  Department of Dermatology and Venereology, Diponegoro University, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia
Noor Wijayahadi scopus  -  Department of Pharmacology, Diponegoro University, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia
Yora Nindita orcid scopus  -  Department of Pharmacology, Diponegoro University, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia
Open Access Copyright 2024 Syifa Nurisma Putri, Farmaditya Eka Putra Mundhofir, Renni Yuniati, Noor Wijayahadi, Yora Nindita

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Abstract

Background: Leprosy is an infectious disease caused by Mycobacterium leprae bacteria which is still the focus of a global problem and causes disability in patients. The degree of disability in leprosy is assessed as mild and severe as a result of the inflammatory process. This study aims to determine the relationship between the degree of disability in leprosy and IL-6 serum levels as an inflammatory biomarker in leprosy patients. Methods: A Cross-sectional observational analytical study on leprosy patients aged 20-60 years, not pregnant, and undergoing treatment at Donorojo Jepara Hospital from March to April 2024. Serum IL-6 levels were analyzed using the ELISA method and tested for correlation with the degree of disability leprosy. Results: Statistical analysis of Spearman's correlation rank test shows a p value = 0.279 and the results of the line pattern on the Scatter dot graph are not linear. Conclusion: There is no correlation between serum IL-6 levels and the degree of disability in leprosy patients at Donorojo Jepara Hospital.

Keywords: Degree of Disability in Leprosy, Leprosy, Serum IL-6

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Keywords: Degree of Disability in Leprosy; Leprosy; Serum IL-6

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Section: Original Articles
Language : EN
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