Correlation between TGF-β Levels and Degree of Wound Healing in Leprosy Ulcer Patients: An Observational Study at dr. Rehatta Regional Hospital Jepara

Rizki Alfarizi; Renni Yuniati; Farmaditya Eka Putra Mundhofir; Noor Wijayahadi; Yora Nindita

doi:10.14710/dmj.v13i3.44999

DOI: https://doi.org/10.14710/dmj.v13i3.44999

Correlation between TGF-β Levels and Degree of Wound Healing in Leprosy Ulcer Patients: An Observational Study at dr. Rehatta Regional Hospital Jepara

*Rizki Alfarizi - Department of Biomedicine, Universitas Diponegoro, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia

Renni Yuniati

- Department of Dermatology and Venereology, Universitas Diponegoro, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia

Farmaditya Eka Putra Mundhofir

- Department of Histology, Universitas Diponegoro, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia

Noor Wijayahadi

- Department of Pharmacology, Universitas Diponegoro, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275, Indonesia

Yora Nindita

- , Indonesia

BibTex Citation Data :

@article{dmj44999,
    author = {Rizki Alfarizi and Renni Yuniati and Farmaditya Eka Putra Mundhofir and Noor Wijayahadi and Yora Nindita},
    title = {Correlation between TGF-β Levels and Degree of Wound Healing in Leprosy Ulcer Patients: An Observational Study at dr. Rehatta Regional Hospital Jepara},
    journal = {Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal)},
  volume = {13},
    number = {3},
    year = {2024},
    keywords = {Leprosy ulcer; Pressure Ulcer Score Healing; Transforming Growth Factor-β; wound healing.)},
    abstract = {  Background:  Ulcers are one form of chronic wounds as one form of complication experienced by leprosy sufferers. In the process of healing wounds such as ulcers, TGF-β has a broad role. Several studies have stated that in chronic wound conditions there is a decrease in TGF-β levels so that the wound is increasingly difficult to heal. This study aims to determine the relationship between TGF-β serum levels and the degree of ulcer wound healing.  Methods:  This study is an observational analysis study with a cross-sectional design and involved 33 leprosy ulcer patients undergoing treatment at the dr. Rehatta Jepara Hospital in the period March-April 2024. Serum TGF-β levels were measured using the Enzyme-linked immunosorbent assay (ELISA) method while the degree of wound healing was assessed by scoring the Pressure Ulcer Scale for Healing (PUSH). Bivariate analysis using the Spearman Correlation Rank Test.  Results:  The correlation test between serum TGF-β levels and the degree of wound healing (p = 0.807) and duration of leprosy as covariate (p = 0.96) showed insignificant results.    Conclusion:  There is no relationship between serum TGF-β levels and the degree of wound healing and duration of leprosy.  },
   issn = {2540-8844},   pages = {158--161}  doi = {10.14710/dmj.v13i3.44999},
    url = {https://ejournal3.undip.ac.id/index.php/medico/article/view/44999}
}

Citation Format:

Abstract

Background: Ulcers are one form of chronic wounds as one form of complication experienced by leprosy sufferers. In the process of healing wounds such as ulcers, TGF-β has a broad role. Several studies have stated that in chronic wound conditions there is a decrease in TGF-β levels so that the wound is increasingly difficult to heal. This study aims to determine the relationship between TGF-β serum levels and the degree of ulcer wound healing. Methods: This study is an observational analysis study with a cross-sectional design and involved 33 leprosy ulcer patients undergoing treatment at the dr. Rehatta Jepara Hospital in the period March-April 2024. Serum TGF-β levels were measured using the Enzyme-linked immunosorbent assay (ELISA) method while the degree of wound healing was assessed by scoring the Pressure Ulcer Scale for Healing (PUSH). Bivariate analysis using the Spearman Correlation Rank Test. Results: The correlation test between serum TGF-β levels and the degree of wound healing (p = 0.807) and duration of leprosy as covariate (p = 0.96) showed insignificant results. Conclusion: There is no relationship between serum TGF-β levels and the degree of wound healing and duration of leprosy.

Fulltext View|Download

Keywords: Leprosy ulcer; Pressure Ulcer Score Healing; Transforming Growth Factor-β; wound healing.)

Article Metrics:

Article Info

Section: Original Articles

Language : EN

In Vol 13, No 3 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)

Recent articles

The Effect of Moringa Leaves Extract on Sperm Motility in Male Mice Exposed to Electromagnetic Radiation of Mobile Phone RELATIONSHIP BETWEEN CLIMATE VARIABLES AND DENGUE INCIDENCE IN WEST INDONESIA Correlation between TGF-β Levels and Degree of Wound Healing in Leprosy Ulcer Patients: An Observational Study at dr. Rehatta Regional Hospital Jepara More recent articles

World Health Organization. Wkly Epidemiol Rec. 2023. p. 409–30 World Health Organization Weekly Epidemiological Record
Kementerian Kesehatan Republik Indonesia. Pedoman Nasional Pelayanan Kedokteran Tata Laksana Kusta. 2019. 1–57 p
Mulianto N, Fiqnasyani SE. Manajemen Ulkus Plantar Lepra. Cermin Dunia Kedokteran. 2023;50(1):45–52
Riyaz N, Sehgal VN. Leprosy: Trophic Skin Ulcers. Skinmed. 2017;15(1):45–51
Upputuri B, Srikantam A, Mamidi RS. Comorbidities associated with non-healing of plantar ulcers in leprosy patients. PLoS Negl Trop Dis. 2020 Jun 1;14(6):1–12
Liarte S, Bernabé-García Á, Nicolás FJ. Role of TGF-β in Skin Chronic Wounds: A Keratinocyte Perspective. Cells. 2020 Jan 28;9(2)
Kiritsi D, Nyström A. The role of TGFβ in wound healing pathologies. Vol. 172, Mechanisms of Ageing and Development. Elsevier Ireland Ltd; 2018. p. 51–8
Ramirez H, Patel SB, Pastar I. The Role of TGFβ Signaling in Wound Epithelialization. Adv Wound Care (New Rochelle). 2014 Jul;3(7):482–91
Kim BC, Kim HT, Park SH, Cha JS, Yufit T, Kim SJ, et al. Fibroblasts from chronic wounds show altered TGF-β-signaling and decreased TGF-β type II receptor expression. J Cell Physiol. 2003 Jun 1;195(3):331–6
Velnar T, Bailey T, Smrkolj V. The Wound Healing Process: an Overview of the Cellular and Molecular Mechanisms. J Int Med Res. 2009;37(5):1528
Demidova-Rice TN, Hamblin MR, Herman IM. Acute and Impaired Wound Healing: Pathophysiology and Current Methods for Drug Delivery, Part 2: Role of Growth Factors in Normal and Pathological Wound Healing: Therapeutic Potential and Methods of Delivery. Adv Skin Wound Care. 2012 Aug;25(8):349–70
Mohanty C, Sahoo SK. Curcumin and its topical formulations for wound healing applications. Vol. 22, Drug Discovery Today. Elsevier Ltd; 2017. p. 1582–92
Barchitta M, Maugeri A, Favara G, San Lio RM, Evola G, Agodi A, et al. Nutrition and wound healing: An overview focusing on the beneficial effects of curcumin. Vol. 20, International Journal of Molecular Sciences. MDPI AG; 2019
Hernández-Pando R, Orozco-Esteves H, Maldonado HA, Aguilar-León D, Vilchis-Landeros MM, Mata-Espinosa DA, et al. A combination of a transforming growth factor-β antagonist and an inhibitor of cyclooxygenase is an effective treatment for murine pulmonary tuberculosis. Clin Exp Immunol. 2006 May;144(2):264–72
Maizels RM. The multi-faceted roles of TGF-β in regulation of immunity to infection. In: Advances in Immunology. Academic Press Inc.; 2021. p. 1–42
Allen SS, Cassone L, Lasco TM, McMurray DN. Effect of Neutralizing Transforming Growth Factor β1 on the Immune Response against Mycobacterium tuberculosis in Guinea Pigs. Infect Immun. 2004 Mar;72(3):1358–63
Olobo JO, Geletu M, Demissie A, Eguale T, Hiwot K, Aderaye G, et al. Circulating TNF-α, TGF-β, and IL-10 in tuberculosis patients and healthy contacts. Scand J Immunol. 2001;53(1):85–91
Goulart IMB, Mineo JR, Foss NT. Production of transforming growth factor-β1 (TGF-β1) by blood monocytes from patients with different clinical forms of leprosy. Vol. 122, Clin Exp Immunol. 2000
Massagué J, Sheppard D. TGF-β signaling in health and disease. Vol. 186, Cell. Elsevier B.V.; 2023. p. 4007–37

Last update:

No citation recorded.

Last update:

No citation recorded.

Authors who publish with this journal agree to the following terms: - Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (CC-BY-NC-SA) that allows others to share the work with an acknowledgment of the work’s authorship and initial publication in this journal. - Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal. - Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).