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The effect combination of black seed (nigella sativa) and glibenclamide on blood glucose levels | Wardani | Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal)

DOI: https://doi.org/10.14710/dmj.v13i3.43369

The effect combination of black seed (nigella sativa) and glibenclamide on blood glucose levels

*Erika Martining Wardani orcid scopus publons  -  Departemen of Nursing, Faculty of Nursing and Midwifery, Universitas Nahdlatul Ulama Surabaya, 60237 Surabaya, East Java, Indonesia, Indonesia
Riezky Faisal Nugroho orcid scopus  -  Departemen of Nutrition, Politeknik Kesehatan Kemenkes Surabaya, 60282 Surabaya, East Java Indonesia, Indonesia

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Abstract

Background: Diabetes Mellitus was considered one of the most alarming pandemics of the twenty-first century before the advent of the COVID-19 pandemic. Glibenclamide (glyburide) is an anti-DM drug of the sulfonylurea class. Several studies have examined one of the medicinal plants, black seed (nigella sativa) as a complementary treatment in the control of DM.

Objective: This study determine the effect of the combination of black seed (nigella sativa) and glibenclamide on reducing blood glucose levels.

Methods: This research design was an experiment using a pretest posttest design with control group design. This study used 24 mice (mus muscullus) which were divided into 4 groups, namely a negative control group that was only given aquadest, a positive control group that was given alloxane as an induction of hyperglycemia and anti-DM drug glibenclamide, treatment group 1 was given aloxane and Black Seed, and treatment group 2 was given alloxane and a combination of black seed and glibenclamid. Data were analyzed using the Paired T Test with α = 0.05.

Results: Blood glucose levels in the black seed and glibenclamid combination treatment group decreased significantly (p=0,00).

Conclusion: the combination of black seed (nigella sativa) and glibenclamide is effective in lowering glucose levels.

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Keywords: effect, Nigella sativa, glibenclamide, blood glucose levels

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