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Association Between Immune-Inflammation Index (SII) and Ferritin with Hepatic Function in Patients with Thalassemia Major | Safitri | Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal)

DOI: https://doi.org/10.14710/dmj.v13i2.42811

Association Between Immune-Inflammation Index (SII) and Ferritin with Hepatic Function in Patients with Thalassemia Major

Titis Yoga Safitri  -  Undergraduate Program, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia, Indonesia
I Edward Kurnia Setiawan L orcid scopus  -  Department of Clinical Pathology, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia, Indonesia
Nahwa Arkhaesi scopus  -  Pediatrics Department, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia, Indonesia
*Nyoman Suci Widyastiti orcid scopus  -  Department of Clinical Pathology, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia, Indonesia

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Abstract

Background: Thalassemia major is associated with ferritin levels and SII values with impaired liver function. Furthermore, the measurement of impaired liver function is carried out using Serum Glutamate Oxaloacetate Transaminase (SGOT) and Serum Glutamate Pyruvate Transaminase (SGPT) levels. Increased SGPT and SGOT levels are indicators of liver necrosis. Objective: This study aimed to prove the association between SII and ferritin with SGPT and SGOT levels in thalassemia major patients. Methods: An observational analysis with a cross-sectional approach was adopted to analyze the medical records of pediatric patients at the Kasuari Clinic of Dr. Kariadi Hospital Semarang from September to October 2023. SII value and ferritin level were the independent variables, while SGOT and SGPT were dependent. Data were collected and analyzed univariately for characteristic description and bivariately using the Spearman test. Results: The median SII value, ferritin level, SGPT level, and SGOT level in thalassemia major patients were 451.73/L, 2097.30 ng/mL, 20.00 U/L, and 40.00 U/L. The results showed there was a moderately significant association between SII values and SGOT levels (p=0.010, r=-0.457) as well as ferritin and SGPT (p=007, r=0.475). There was no significant association between SII values and SGPT levels, as shown by a p-value of 0.122. Similarly, there was no association between ferritin and SGOT levels (p=0.088). Conclusion: A moderately significant association was found between SII values and SGOT levels, as well as ferritin levels and SGPT levels in thalassemia major patients. 

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Keywords: Thalassemia Major; SII; Ferritin Level; SGPT Level; SGOT Level

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  1. References
  2. Rujito L. Talasemia : Genetik Dasar dan Pengelolaan Terkini. Siswandari WI, Lestari DWD, editors. Unsoed Press; 2019
  3. Kementerian Kesehatan Republik Indonesia. Putuskan Mata Rantai Talasemia, untuk Indonesia Lebih Sehat [Internet]. 2019. Available from: https://p2ptm.kemkes.go.id/subdit-penyakit-kanker-dan-kelainan-darah/putuskan-mata-rantai-talasemia-untuk-indonesia-lebih-sehat
  4. Penelitian Badan Kesehatan Pengembangan. Laporan Hasil Riset Kesehatan Dasar (RISKESDAS). In: Provinsi Jawa Tengah Tahun 2007 [Internet [Internet]. 2007. Available from: https://labdata.litbang.kemkes.go.id/images/download/laporan/RKD/2007/lap_rkd07_prov.zip
  5. Anggraini DM, Ujiani S. Hubungan Kadar Feritin Dengan Aktivitas Enzim SGOT Dan SGPT Pasien Thalasemia Di RSUD Abdul Moeloek Provinsi Lampung Tahun 2017. J Analis Kes. 2017;6(2):632–9
  6. Bazi A, Shahramian I, Yaghoobi H, Naderi M, Azizi H. The Role of Immune System in Thalassemia Major: A Narrative Review. J Pediatr Rev. 2017;6(2):29–36. doi: 10.5812/jpr.14508
  7. Li C, Tian W, Zhao F, Li M, Ye Q, Wei Y. Systemic immune-inflammation index, SII, for prognosis of elderly patients with newly diagnosed tumors. Oncotarget. 2018;9(82):35293–9. doi: 10.18632/oncotarget.24293
  8. Kurniawan MP, Retnowulan H. Systemic Immune-Inflammation Index (SII) sebagai Faktor Prognosis Mortalitas pada Adenokarsinoma Paru Stadium IV [Internet [Internet]. Yogyakarta; 2020. Available from: http://etd.repository.ugm.ac.id/
  9. Cipta CE, Hutajulu SH, Sulistyoningrum DC. Prognostic Factor of Systemic Immune Inflammation (SII) in Predicting Overall Survival (OS. In: Patient With Metastatic Colorectal Cancer at RSUP Dr Sardjito [Internet [Internet]. Yogyakarta; 2019. Available from: http://etd.repository.ugm.ac.id/
  10. Nam KW, Kwon HM, Jeong HY, Park JH, Kwon H. Systemic immune-inflammation index is associated with white matter hyperintensity volume. Sci Rep. 2022;12(1). doi: 10.1038/s41598-022-11575-0
  11. Wang Q, Zhu D. The prognostic value of systemic immune-inflammation index (SII) in patients after radical operation for carcinoma of the stomach in gastric cancer. J Gastrointest Oncol. 2019;10(5):965–78. doi: 10.21037/jgo.2019.05.03
  12. Origa R. β-Thalassemia. Genet Med. 2017;19(6):609–19. doi: 10.1038/gim.2016.173
  13. Kumar AM, Tiwari A. Iron Overload in Beta Thalassaemia Major and Intermedia Patients. Maedica (Bucur). 2013;8(4):328–32
  14. Husada S, Agustina R, Mandala Z, Indah RN. Hubungan Kadar Feritin Serum dengan Kadar Enzim SGOT dan SGPT pada Pasien Thalasemia β Mayor. JIKSH. 2020;11(1):252–7
  15. Bajwa H, Basit H. Thelassemia: Brenner’s Encyclopedia of Genetics [Internet]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK545151/
  16. Koreti S, Gaur BK, Das G, Gaur A. Study of Serum ferritin levels in β-Thalassemia major children. Int J Pediatr Res. 2018;5(6):308–13. DOI: https://doi.org/10.17511/ijpr.2018.i06.02
  17. Farihatun A, Siti E, Janah N, Dewi Y, Edhiatmi KM. SGPT Levels (Serum Glutamic Pyruvat Transaminase) on Pil KB Contraception Acceptors. Jur Kes STIKes Mu Cis. 2020;7(2):39–43. DOI: https://doi.org/10.52221/jurkes.v7i2.93
  18. Salama KM, Ibrahim OM, Kaddah AM, Boseila S, Ismail LA, Abdel Hamid MM. Liver enzymes in children with beta-Thalassemia major: Correlation with iron overload and viral hepatitis. OA Maced J Med Sci. 2015 Jun 15; DOI: https://doi.org/10.3889/oamjms.2015.059
  19. Lomanorek VY, Assa YA, Mewo YM. Gambaran Kadar Serum Serum Glutamic Oxaloacetic Transaminase (SGOT) pada Perokok Aktif Usia > 40 Tahun. eBM. 2016;4(1). DOI: https://doi.org/10.35790/ebm.v4i1.11046
  20. Reza A, Rachmawati B. Perbedaan Kadar SGOT dan SGPT antara Subyek dengan dan Tanpa Diabetes Mellitus. JKD. 2017;6(2):158–66. https://doi.org/10.14710/dmj.v6i2.18530
  21. Joniarti F, Dia Rofinda Z. Korelasi Kadar Feritin dengan Enzim Transaminase Penyandang Talasemia Beta Mayor Tergantung Transfusi. MKA. 2022;45(3):327–33. DOI: https://doi.org/10.25077/mka.v45.i3.p327-333.2022
  22. Song Y, Guo W, Li Z, Guo D, Li Z, Li Y. Systemic immune-inflammation index is associated with hepatic steatosis: Evidence from NHANES 2015-2018. Front Immunol. 2022;13:1–9. https://doi.org/10.3389/fimmu.2022.1058779
  23. Aminuddin MF, Darmawan AB, Rujito L. Korelasi Feritin dengan Sitokin Proinflamasi pada Pasien Talasemia Beta Di Kota Samarinda Kalimantan Timur. J Indon Med Assoc. 2022;72(2):77–82
  24. Kuswoyo NH, Natadidjaja IR. Korelasi antara kadar procalcitonin dengan serum transaminase pada pasien sepsis: sebuah studi pendahuluan. J Biomedika dan Kesehat. 2019;2(1):15–9. DOI: https://doi.org/10.18051/JBiomedKes.2019.v2.15-19
  25. Yutarti CS, Susilowati IT. Hubungan Kadar Feritin Serum dengan Tes Fungsi Hati pada Pasien Thalasemia Mayor. J Kes. 2023;14(1):42–8. DOI: https://doi.org/10.26630/jk.v14i1.3360
  26. Nuari A, Tjiptaningrum A, Ristyaningrum P, Basuki W. Hubungan Kadar Feritin Serum dengan Aktivitas Enzim AST, ALT, dan Status Gizi pada Anak Talasemia β Mayor. J Agromed Unila. 2016;3(1):26–9
  27. Tejasari RK, Reniarti L, Effendi SH. Faktor Risiko Hiperkoagulasi pada Thalassemia Anak. Sari Pediatr. 2015;16(6):427–33. DOI: http://dx.doi.org/10.14238/sp16.6.2015.427-33
  28. Gluba-Brzózka A, Franczyk B, Rysz-Górzyńska M, Rokicki R, Koziarska-Rościszewska M, Rysz J. Pathomechanisms of immunological disturbances in β-thalassemia. Int J Mol Sci. 2021;22(18). doi: 10.3390/ijms22189677
  29. Wahidiyat PA, Iskandar SD, Chozie NA, Sekarsari D. Hemostatic abnormalities in children with thalassemia major and liver iron overload. Pediatr Indones. 2018;58(4):175–9. DOI: https://doi.org/10.14238/pi58.4.2018.175-9

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