DOI: https://doi.org/10.14710/dmj.v13i2.43036

The Effect of Lemon Skin Extract on Uric Acid Levels of Hyperuricemia Male Wistar Rats

Revi Ardiansyah  -  Undergraduate Program, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia, Indonesia
Noor Wijayahadi  -  Departement of Pharmacology and Therapy, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia, Indonesia
Endang Mahati  -  Departement of Pharmacology and Therapy, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia, Indonesia
*Yora Nindita orcid scopus publons  -  Departement of Pharmacology and Therapy, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia, Indonesia

Citation Format:
Abstract

Background: Purine metabolism, carried out in the liver, results in the production of uric acid. Hyperuricemia is a condition of elevated level of uric acid in the blood that can lead to gout if untreated. Lemon (Citrus Limon.) contains flavonoids which act as antioxidants and have the potential role as antihyperuricemia. Aim: To determine the effect of lemon peel extract on uric acid levels. Methods: Thirty-six male wistar rats from Farmhouse Ungaran were randomly divided into 6 groups, consists of healthy control group (K0), hyperuricemic control (K1), allopurinol control (K2), and 3 treatment groups (P1, P2, P3). Hyperuricemia induced with administration of block broth and potassium oxonate for 4 weeks. Lemon peel extract doses of 17,5, 35, and 70 mg/kg BW, and allopurinol 90 mg/kg BW was given orally for 2 weeks. Statistical analysis was conducted to evaluate differences among groups before and after the intervention. Results: There was a significant difference (p<0,05) in uric acid levels before and after intervention of lemon peel extract in groups K1, K2, and P3. Meanwhile, in groups K0, P1, and P2, there were no significant differences observed. In the pre-test uric acid levels, there was a significant difference (p<0,05) between the K0 group and K1, K2, P1, P2, and P3. Conclusion: There were no significant differences observed in the uric level acid of the treatment and control group after intervention, but there were significant differences in the effects of graded dosages between the treatment groups. 

Fulltext View|Download
Keywords: Lemon, Uric Acid, Rats

Article Metrics:

Article Info
Section: Original Articles
Language : EN
Recent articles
Factors Associated with The Choice of Place of Delivery in Coastal Communities in The Working Area of Bonegunu Community Health Center North Buton District Effects of Garcinia Mangostana Linn Pericarp Extract and Physical Exercise on Atheroembolic Histopathologic Features Kidney in Wistar Rats with Metabolic Syndrome The Effect of Lemon Skin Extract on Uric Acid Levels of Hyperuricemia Male Wistar Rats Case Report: Diagnosis and Management of Body Stalk Anomaly Case Report: Successful Management of Ischemic Stroke Patients with Pneumonia, Diabetes Mellitus, and Hypertension in The ICU More recent articles
  1. REFERENCES
  2. Kusumayanti GAD, Komang Wiardani N, Putu P, Sugiani S, Jurusan D, Politeknik G, et al. Diet Mencegah dan Mengatasi Gangguan Asam Urat. Jurnal Ilmu Gizi. 2014;5(1):69–78
  3. Flaurensia V, Kussoy M, Ferdinand RK, Program W, Keperawatan SI, Kedokteran F. Kebiasaan Makan Makanan Tinggi Purin dengan Kadar Asam Urat di Puskesmas. Journal Keperawatan (J-Kp. 2019;7(2):2–4. DOI: 10.35790
  4. Thayibah R, Ariyanto Y, Ramani Bagian Epidemiologi dan Biostatistika Fakultas Kesehatan Masyarakat Universitas Jember Jalan Kalimantan A. Hiperurisemia Pada Remaja di Wilayah Kerja Puskesmas Arjasa Kabupaten Situbondo Hyperuricemia in Adolescents (16-24 Years Old) in Arjasa Primary Health Center, Situbondo Regency. Pustaka Kesehatan. 2018 Jan 17;6(1):38–45. DOI: 10.19184
  5. Annissa S, Adi Sumiwi S, Raya Bandung Sumedang Km J. Aktivitas Antihiperurisemia beberapa Tanaman di Asia : Article Review. Farmaka. 2017 Jul 8;15(1):153–66
  6. Anshori AM, Wiraguna AAGP, Pangkahila W. Pemberian oral ekstrak kulit buah lemon (Citrus limon) menghambat peningkatan ekspresi MMP-1 (matrix metaloproteinase-1) dan penurunan jumlah kolagen pada tikus putih galur wistar jantan (Rattus norvegicus) yang dipajan sinar UV-B. eBiomedik. 2017;5(1). DOI: 10.35790
  7. Rahmawati I, Ekacahyaningtyas M, Program Studi Sarjana Keperawatan STIKes Kusuma Husada Surakarta M, Program Studi Sarjana Keperawatan STIKes Kusuma Husada Surakarta D. Pengaruh Infused Water Lemon Terhadap Kadar Asam Urat Lansia di Posyandu Lansia Sukorejo Wonogiri. 2019;1(1):5–9
  8. Pratiwi; RPA. Pengaruh Pemberian Jus Lemon Terhadap Penurunan Kadar Asam Urat pada Dewasa Usia ≥ 30 Tahun. 2019;1(1):7–14. DOI: 10.37148
  9. Chen L, Li M, Wu JL, Li JX, Ma ZC. Effect of lemon water soluble extract on hyperuricemia in a mouse model. Food Funct. 2019 Sep 1;10(9):6000–8. DOI: 10.1039
  10. Himawan H, Sulastri L, Holisoh S. Aktivitas Fraksii n-Heksana , Etil Asetat, dan Air Dari Ekstrak Etanol 96% Daun Landep (Barleria Prionitis L.) Terhadap Penurunan Kadar Asam Urat Darah Tikus Putih Jantan. Jurnal Abdidas. 2020 Jun 9;1(2):80–7. DOI: 10.31004
  11. Coelho MOC, Monteyne AJ, Kamalanathan ID, Najdanovic-Visak V, Finnigan TJA, Stephens FB, Wall BT. Short-Communication: Ingestion of a Nucleotide-Rich Mixed Meal Increases Serum Uric Acid Concentrations but Does Not Affect Postprandial Blood Glucose or Serum Insulin Responses in Young Adults. Nutrients. 2020 Apr 17;12(4):1115. doi: 10.3390/nu12041115.PMID:32316391;PMCID:PMC7230981
  12. Hastuti VN, Murbawani EA, Wijayanti HS. Hubungan Asupan Protein Total dan Protein Kedelai Terhadap Kadar Asam Urat Dalam Darah Wanita Menopause. Journal of Nutrition College]. 2018;7(2):54–6. DOI: 10.14710
  13. Addinurrahmat D. Pengaruh Infusa Daun Jeruju (Acanthus Ilicifolius) Terhadap Kadar Asam Urat Darah Tikus (Rattus Novergicus) Hiperurisemia. Universitas Brawijaya. 2017;
  14. Nur K, Sumiwi A. Berbagai Tanaman Sebagai Antihiperurisemia. Bandung; 2019
  15. Dwiitiyanti. Anti-hyperuricemia Effect of Water Fraction Cinnamon (Cinnamomum burmannii (Ness & T. Ness) Blume) on White Male Rats. 2018. 104–106 p. DOI: 10.5220
  16. Rasyad AA. Pengaruh pemberian ekstrak nanas (Ananas comocus (L.) Merr) terhadap penurunan kadar asam urat pada tikus jantan hiperurisemia. Ilmiah Farmasi. 2019;15(2):64–9. DOI: 10.20885
  17. Qurie A, Preuss CV, Musa R. Allopurinol. StatPearls; 2023 Januari
  18. Azizah et al. Pengaruh Penambahan Kulit Buah Lemon (Citrus limon (L.)) Kering Terhadap Karakteristik Organoleptik, Total Padatan Terlarut, pH, Kandungan Vitamin C dan Total Fenol Teh Celup Daun Kelor (Moringa oleifera). Teknologi Pangan. 2021;30–9. DOI: 10.14710
  19. Feng S, Wu S, Xie F, Yang CS, Shao P. Natural compounds lower uric acid levels and hyperuricemia: Molecular mechanisms and prospective. Trends Food Sci Technol. 2022 May 1;123:87–102. DOI: 10.1016
  20. Abdulkadir W, Papeo D, et al. Efek Antihiperurisemia Ekstrak Etanol Daun Pandan (Pandanus Amaryllifolius) pada Mencit (Mus Musculus). Journal Syifa Sciences and Clinical Research. Vol 4; 2. 2022
  21. Darmayanti EY, Puspitasari CE, Hasina R. Profil Drug Related Problems (DRPs) Penggunaan Antibiotik pada Pasien Anak dengan Diare Infeksi di RSUD Provinsi NTB Tahun 2018. Jurnal Sains dan Kesehatan. 2021 Jun 30;3(3):500–4. DOI: 10.25026

Last update:

No citation recorded.

Last update:

No citation recorded.