DOI: https://doi.org/10.14710/dmj.v12i5.38564

Correlation between HbA1c Levels with Several Methods of estimated Glomerular Filtration Rate Calculation : Study in type-2 diabetes mellitus patients

Septian Eka Prasetyo  -  Undergraduate Program, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia, Indonesia
Edward Kurnia Setiawan Limijadi  -  Departement of Clinical Pathology, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia, Indonesia
Dwi Lestari Partiningrum  -  Departement of Internal Medicine, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia, Indonesia
*Meita Hendrianingtyas orcid scopus  -  Dept of Clinical Pathology, Faculty of Medicine Universitas Diponegoro Semarang, Indonesia

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Abstract

ABSTRACT

Background: Diabetes Mellitus is a long-term chronic disease characterized by blood glucose levels enhancement (hyperglycemia). Diabetes is closely related to hyperglycemia conditions. Prolonged hyperglycemic conditions can initiate abnormal interactions of metabolic and hemodynamic factors and stimulate the establishment of fibronectin and collagen, including affecting eGFR values. This study analyzed the correlation between HbA1c level and several methods of calculating eGFR in patients with type-2 diabetes mellitus.

Objective: Analyzing the correlation between HbA1c levels and several methods of calculating eGFR (CKD-EPI, MDRD, and CG) in patients with type-2 diabetes mellitus.

Method: This study was a cross-sectional observational study on 85 research subjects aged over 18 in February to November 2021. The data were taken from medical records of type-2 diabetes mellitus patients at RSND Semarang. The statistical analysis used the Pearson test.

Results: The Pearson results showed that there was a significant correlation between HbA1c levels and several methods of calculating eGFR in patients with type-2 diabetes mellitus (p=0,000; r=0,430 in the CKD-EPI method, p=0,000; r=0,384 in the MDRD method, p=0,001; r=0,361 in the CG method).

Conclusion: There was a significant positive correlation between HbA1c levels and eGFR CG, MDRD, and CKD-EPI methods in patients with type-2 diabetes mellitus, characterized by increased HbA1c levels and still high eGFR values.

Keywords: Diabetes mellitus, HbA1c, eGFR, CKD-EPI, MDRD, CG
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Keywords: Diabetes mellitus, HbA1c, eGFR, CKD-EPI, MDRD, CG

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Language : EN
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  7. Rudijanto A, Yuwono A, Shahab A, Manaf A, Pramono B, Lindarto D. Konsensus Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 di Indonesia. Jakarta; 2015
  8. Sherwani SI, Khan HA, Ekhzaimy A, Masood A, Sakharkar MK. Significance of HbA1c Test in Diagnosis and Prognosis of Diabetic Patients. Biomark Insights. 2016;11:95–104
  9. Edwina DA, Manaf A, Efrida E. Pola Komplikasi Kronis Penderita Diabetes Melitus Tipe 2 Rawat Inap di Bagian Penyakit Dalam RS. Dr.M. Djamil Padang. J Kesehat Andalas. 2015;4(1)
  10. Michels WM, Grootendorst DC, Verduijn M, Elliott EG, Dekker FW, Krediet RT. Performance of the Cockcroft-Gault, MDRD, and New CKD-EPI Formulas in Relation to GFR, Age, and Body Size. Clin J Am Soc Nephrol. 2010;5:1003–9
  11. Mula-Abed WA, Al Rasadi K, Al- Riyami D. Estimated Glomerular Filtration Rate (eGFR): A Serum Creatinine-based Test for the Detection of Chronic Kidney Disease and Impact on Clinical Practice. Oman Med J. 2012;27(2):108–13
  12. Sugondo AT, Ardiany D, Nuswantoro D, Notopuro PB. Relationship between HbA1c Levels with eGFR and Blood Pressure in Type 2 Diabetes Mellitus Patients in the Department of Internal Medicine Dr. Soetomo General Hospital Surabaya. Biomol Heal Sci J. 2019;2(2):117
  13. Flack J, Adekola B. Blood Pressure and the New ACC/AHA Hypertension Guidelines. Trends Cardiovasc Med. 2020;30(3):160–4
  14. Lastra G, Syed S, Kurukulasuriya L, Manrique C, Sowers J. Type 2 Diabetes Mellitus and Hypertension: An Update. Endocrinol Metab Clin. 2014;43(1):103–22
  15. William D, Ludong M. Gambaran estimated Glomerular Filtration Rate pada Individu dengan Hiperurisemia di Rumah Sakit Sumber Waras Periode Tahun 2014- 2016. Tarumanagara Med J. 2019;1(2):302–7
  16. Susanti E, Latifah I, Nugraha AD. Hubungan NILAI HbA1c dengan Laju Filtrasi Glomerulus (LFG) pada Pasien Diabtes Melitus Tipe 2 di Rumah Sakit PMI Bogor. J Ilm Anal Kesehat. 2020;6(2)
  17. Sukohar A, Damara A, Graharti R. Hubungan Nilai HbA1c dengan Laju Filtrasi Glomerulus (LFG) pada Pasien Diabetes Melitus Tipe 2 di Rumah Sakit Umum Daerah H. Abdul Moeloek Bandar Lampung. JK Unila. 2018;2:37
  18. Gahung RY, Pandelaki K, Moeis ES. Hubungan Kadar HbA1C dengan Estimasi Filtrasi Glomerulus pada Pasien DM Tipe 2. J e-Clinic. 2016;4(1)
  19. Sisodia RK, Chouhan M. The Study of Correlation between Body Mass Index and Glycemic Control-HbA1c in Diabetes Type 2 Patients. Int J Adv Med. 2019;6(6):1788
  20. Kurniati A, Tahono T. Angka Banding Albumin Kreatinin Air Kemih dan HbA1C serta Esitimasi Laju Filtrasi Glomerulus pada Pasien Diabetes Melitus. Indones J Clin Pathol Med Lab. 2018;21(3):250–6
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  22. Majid F, Uwan W, Zakiah M. Hubungan Kadar HbA1c terhadap Laju Filtrasi Glomerulus dan Proteinuria pada Penderita Diabetes Melitus Tipe 2. J Cerebellum. 2020;6(1):12–6

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