PENGARUH PEMBERIAN BUAH PEPAYA (CARICA PAPAYA L) TERHADAP KADAR KOLESTEROL TOTAL PADA  TIKUS SPRAGUE DAWLEY DENGAN HIPERKOLESTEROLEMIA

Claudia Kartika Dewi; Enny Probosari

doi:10.14710/jnc.v1i1.427

DOI: https://doi.org/10.14710/jnc.v1i1.427

PENGARUH PEMBERIAN BUAH PEPAYA (CARICA PAPAYA L) TERHADAP KADAR KOLESTEROL TOTAL PADA TIKUS SPRAGUE DAWLEY DENGAN HIPERKOLESTEROLEMIA

Claudia Kartika Dewi , Enny Probosari

Program Studi Ilmu Gizi Fakultas Kedokteran Universitas Diponegoro, Indonesia

Published: .

BibTex Citation Data :

@article{JNC427,
    author = {Claudia Dewi and Enny Probosari},
    title = {PENGARUH PEMBERIAN BUAH PEPAYA (CARICA PAPAYA L) TERHADAP KADAR KOLESTEROL TOTAL PADA  TIKUS SPRAGUE DAWLEY DENGAN HIPERKOLESTEROLEMIA},
    journal = {Journal of Nutrition College},
  volume = {1},
    number = {1},
    year = {2012},
    keywords = {hypercholesterolemia; papaya; total cholesterol},
    abstract = {ABSTRACT  Background : Coronary Heart Disease (CHD) is a cardiovascular disease wich primary  cause of deadness in any countries. It is one of the causes hypercholesterolemia. Papaya fruit has many benefits for health such as anti-inflammatory, anti-hypertension, it can reduce triglyceride levels and it can reduce total cholesterol levels in the blood. The purpose of this study is to investigate the effect of administration of papaya (Carica papaya L) for total cholesterol levels in Sprague Dawley rats with hypercholesterolemia. Method : This research was true-experimental pre-post test control with rondomized group design. Subjects were male Sprague Dawley rats aged 7-8 weeks, weight 100-200 grams are a given blended of  papaya fruit as much as 5.4 g, 7.2 g and 9.0 g per within 4 weeks. Total cholesterol levels are determined by the CHOD-PAP method Enzimatic Precipitation Colorimeter Test. Data normality was tested by Shapiro Wilks. Data were analyzed by ANOVA test, followed by LSD test .Result : the research shows that giving papaya 5.4 g per day is able to reduce  total cholesterol were significantly (p = 0.001). Giving papaya in dosage of 7,2 g can reduce cholesterol but it is insignificance (p= 0,086) and giving papaya in dosage of 9,0 g can not reduce the cholesterol (p= 1,000). Conclusion : Giving papaya dosage 5.4 gr, 7.2 g and 9 g can not lower significantly of total cholesterol levels   Key Words : hypercholesterolemia, papaya, total cholesterol   },
   issn = {2622-884X},   pages = {93--98}  doi = {10.14710/jnc.v1i1.427},
    url = {https://ejournal3.undip.ac.id/index.php/jnc/article/view/427}
}

Citation Format:

Abstract

ABSTRACT

Background : Coronary Heart Disease (CHD) is a cardiovascular disease wich primary cause of deadness in any countries. It is one of the causes hypercholesterolemia. Papaya fruit has many benefits for health such as anti-inflammatory, anti-hypertension, it can reduce triglyceride levels and it can reduce total cholesterol levels in the blood. The purpose of this study is to investigate the effect of administration of papaya (Carica papaya L) for total cholesterol levels in Sprague Dawley rats with hypercholesterolemia.
Method : This research was true-experimental pre-post test control with rondomized group design. Subjects were male Sprague Dawley rats aged 7-8 weeks, weight 100-200 grams are a given blended of papaya fruit as much as 5.4 g, 7.2 g and 9.0 g per within 4 weeks. Total cholesterol levels are determined by the CHOD-PAP method Enzimatic Precipitation Colorimeter Test. Data normality was tested by Shapiro Wilks. Data were analyzed by ANOVA test, followed by LSD test
.Result : the research shows that giving papaya 5.4 g per day is able to reduce total cholesterol were significantly (p = 0.001). Giving papaya in dosage of 7,2 g can reduce cholesterol but it is insignificance (p= 0,086) and giving papaya in dosage of 9,0 g can not reduce the cholesterol (p= 1,000).
Conclusion : Giving papaya dosage 5.4 gr, 7.2 g and 9 g can not lower significantly of total cholesterol levels

Key Words : hypercholesterolemia, papaya, total cholesterol

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Keywords: hypercholesterolemia; papaya; total cholesterol

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Section: Jilid 2

Language : EN

In Vol 1, No 1 (2012): Oktober 2012

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