DOI: https://doi.org/10.14710/jnc.v12i2.36269

POTENSI TERAPEUTIK KOPI HIJAU TERHADAP OBESITAS

1Program Studi Pendidikan Profesi Dietisien Fakultas Ilmu Kesehatan, Universitas Brawijaya, Indonesia

2Departemen Gizi Fakultas Ilmu Kesehatan, Universitas Brawijaya, Indonesia

Received: 11 Oct 2022; Published: 30 Apr 2023.

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Abstract

ABSTRACT

Background: Obesity is a nutritional problem caused by excess food intake. This increases the risk of degenerative diseases. Consumption of green coffee affects the incidence of obesity, which can improve body composition, lipid profile, and inflammatory response. Green coffee is defined as coffee beans that haven’t been roasted. Green coffee contains caffeine, trigonellin, and chlorogenic acid. These compounds are widely used for health both in the form of brewed coffee or supplements.

Objective: Analyzing the benefits of green coffee to deal with obesity problems.

Method: Literature review using research articles in the last 10 years from 4 databases (ScienceDirect, PubMed, ProQuest, and ResearchGate) using keywords: green coffee, obesity, inflammation, lipid profile, weight, BMI. Study selection was based on the 2009 PRISMA Statement and 24 studies were included in this review.

Results: In 22 studies, green coffee can improve body composition (weight, BMI, WC, and body fat percentage), lipid profile (LDL, triglycerides and HDL) and inflammatory conditions in human and mice. Nonetheless, there were 2 studies that didn’t show a significant effect of green coffee on reducing body weight and improving lipid profiles in mice and humans. This is likely due to differences in the source or dose of chlorogenic acid given. In addition, green coffee can be used as an anti-inflammatory because it contains pyrocatechool.

Conclusion: Green coffee has therapeutic potential because it contains chlorogenic acid, caffeine, and trigonellin which show remedial effects on body composition, lipid profile and inflammatory conditions.

Keywords: Anti-inflammatory; Body composition; Green coffee; Lipid profile; Obesity.


ABSTRAK

Latar Belakang: Obesitas merupakan salah satu permasalahan gizi akibat asupan makanan berlebih. Hal tersebut meningkatkan risiko penyakit degeneratif. Konsumsi kopi hijau berpengaruh terhadap kejadian obesitas, dimana dapat memperbaiki komposisi tubuh, profil lipid, serta respon inflamasi. Kopi hijau didefinisikan sebagai biji kopi yang belum dilakukan proses pemanggangan. Kopi hijau mengandung kafein, trigonelin, dan polifenol dimana senyawa polifenol yang utama terkandung pada kopi hijau adalah asam klorogenat. Senyawa tersebut banyak dimanfaatkan untuk kesehatan baik dalam bentuk bubuk kopi yang diseduh ataupun suplemen.

Tujuan: Menganalisis manfaat kopi hijau untuk menangani masalah obesitas.

Metode: Literature review menggunakan artikel penelitian dalam 10 tahun terakhir dari 4 database (ScienceDirect, PubMed, ProQuest, dan ResearchGate) menggunakan keywords: green coffee, obesity, inflammation, lipid profile, weight, BMI. Seleksi studi mengacu pada PRISMA Statement 2009 dan ditetapkan 24 studi yang disertakan dalam review ini.

Hasil: Pada 22 penelitian, kopi hijau dapat memperbaiki komposisi tubuh (berat badan, IMT, lingkar pinggang, dan persentase lemak tubuh), profil lipid (LDL, trigliserida dan HDL) serta kondisi inflamasi pada subjek manusia dan mencit. Meskipun demikian, terdapat 2 penelitian yang tidak menunjukkan efek signifikan kopi hijau dalam penurunan berat badan dan perbaikan profil lipid pada mencit dan manusia. Hal ini kemungkinan terjadi karena adanya perbedaan sumber atau dosis asam klorogenat yang diberikan. Selain itu, kopi hijau dapat digunakan sebagai anti-inflamasi karena mengandung zat pyrocatechol.

Simpulan: Kopi hijau memiliki potensi terapeutik karena mengandung asam klorogenat, kafein, dan trigonelin yang menunjukkan efek perbaikan pada komposisi tubuh, profil lipid dan kondisi inflamasi.

Kata kunci: Anti-inflamasi; Komposisi tubuh; Kopi hijau; Obesitas; Profil lipid.

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Keywords: Anti-inflamasi; Komposisi tubuh; Kopi hijau; Obesitas; Profil lipid.

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  9. Rahardjo P. Kopi. Swadaya: Jakarta, 2012Isnindar I, Wahyuono S, Widyarini S, Yuswanto Y. Aktivitas antioksidan buah kopi hijau merapi. JPSCR: Journal of Pharmaceutical Science and Clinical Research, 2017; 2(2): 130. https://doi.org/10.20961/jpscr.v2i2.11040
  10. Zain MZM, Shori AB, Baba AS. Composition and health properties of coffee bean. European Journal of Clinical and Biomedical Sciences, 2017; 3(5): 97. https://doi.org/ 10.11648/j.ejcbs.20170305.13
  11. Pilipczuk T, Kusznierewicz B, Zielińska D, Bartoszek A. The influence of roasting and additional processing on the content of bioactive components in special purpose coffees. J Food Sci Technol 2015; 52(9): 5736–5744. https://doi.org/10.1007/s13197-014-1646-6
  12. Jeszka-Skowron M, Sentkowska A, Pyrzyńska K, De Peña MP. Chlorogenic acids, caffeine content and antioxidant properties of green coffee extracts: influence of green coffee bean preparation. European Food Research and Technology. 2016; 242: 1403–1409. https://doi.org/10.1007/s00217-016-2643-y
  13. USDA. Indonesia Coffee Annual Report 2019. USDA Foreign Agricultural Service 2019: 7
  14. Parnadi F, Loisa R. Analisis daya saing ekspor kopi indonesia di pasar internasional. Jurnal Manajemen Bisnis dan Kewirausahaan, 2018; 2(4): 52–62. https://doi.org/10.24912/jmbk.v2i4.4863
  15. Roshan H, Nikpayam O, Sedaghat M, Sohrab G. Effects of green coffee extract supplementation on anthropometric indices, glycaemic control, blood pressure, lipid profile, insulin resistance and appetite in patients with the metabolic syndrome: A randomised clinical trial. British Journal of Nutrition 2018; 119(3): 250–258. https://doi.org/10.1017/S000711451700343
  16. Williams LT, Mitchell LJ, Barnes K, Ball L, Ross LJ, Sladdin I. How effective are dietitians in weight management? A systematic review and meta-analysis of randomized controlled trials. Healthcare (Switzerland), 2019; 7(1): 20. https://doi.org/10.3390/healthcare7010020
  17. Haidari F, Samadi M, Mohammadshahi M, Jalali M, Engali K, Haidari F et al. Energy restriction combined with green coffee bean extract affects serum adipocytokines and the body composition in obese women. 2017; 26(6): 1048–1054. https://doi.org/10.6133/apjcn.022017.03
  18. Salamat S, Sharif SS, Nazary-Vanani A, Kord-Varkaneh H, Clark CCT, Mohammadshahi M. The effect of green coffee extract supplementation on serum oxidized LDL cholesterol and total antioxidant capacity in patients with dyslipidemia: A randomized, double-blind, placebo-controlled trial. Eur J Integr Med, 2019; 28: 109–113. Available from: https://pureportal.coventry.ac.uk/en/publications/the-effect-of-green-coffee-extract-supplementation-on-serum-oxidi
  19. Revuelta-Iniesta R, Al-Dujaili EAS. Consumption of green coffee reduces blood pressure and body composition by influencing 11 β-HSD1 enzyme activity in healthy individuals: A pilot crossover study using green and black coffee. Biomed Res Int. 2014; 2014: 482704. https://doi.org/10.1155/2014/482704
  20. Sarriá B, Martínez-López S, Mateos R, Bravo-Clemente L. Long-term consumption of a green/roasted coffee blend positively affects glucose metabolism and insulin resistance in humans. Food Research International. 2016; 89: 1023–1028. https://doi.org/10.1016/j.foodres.2015.12.032
  21. Sarriá B, Martínez-López S, Sierra-Cinos JL, García-Diz L, Mateos R, Bravo-Clemente L. Regularly consuming a green/roasted coffee blend reduces the risk of metabolic syndrome. Eur J Nutr. 2018; 57(1): 269–278. https://doi.org/10.1007/s00394-016-1316-8
  22. Hosseinabadi S, Rafraf M, Mahmoodzadeh A, Asghari-Jafarabadi M, Asghari S. Effects of green coffee extract supplementation on glycemic indexes, leptin, and obesity values in patients with non-alcoholic fatty liver disease. J Herb Med, 2020; 22: 100340. https://doi.org/10.1016/j.hermed.2020.100340
  23. Sarriá B, Sierra-Cinos JL, García-Diz L, Martínez-López S, Mateos R, Bravo-Clemente L. Green/Roasted Coffee May Reduce Cardiovascular Risk in Hypercholesterolemic Subjects by Decreasing Body Weight, Abdominal Adiposity and Blood Pressure. Foods. 2020; 9(9): 1191. https://doi.org/10.3390/foods9091191
  24. Hosseinabadi S, Rafraf M, Asghari S, Asghari-Jafarabadi M, Vojouhi S. Effect of green coffee extract supplementation on serum adiponectin concentration and lipid profile in patients with non-alcoholic fatty liver disease: A randomized, controlled trial. Complement Ther Med, 2020; 49: 102290. https://doi.org/10.1016/j.ctim.2019.102290
  25. Sudeep H, Shyam Prasad K. Supplementation of green coffee bean extract in healthy overweight subjects increases lean mass/fat mass ratio: A randomized, double-blind clinical study. SAGE Open Med, 2021; 9: 205031212110025. https://doi.org/10.1177/20503121211002590
  26. Rashidi Z, Beigi R, Mardaniyan Ghahfarrokhi M, Faramarzi M, Banitalebi E, Jafari T et al. Effect of elastic band resistance training with green coffee extract supplementation on adiposity indices and TyG-related Indicators in Obese Women. Obes Med, 2021; 24(11): 100351. https://doi.org/10.1016/j.obmed.2021.100351
  27. Li Kwok Cheong JD, Croft KD, Henry PD, Matthews V, Hodgson JM, Ward NC. Green coffee polyphenols do not attenuate features of the metabolic syndrome and improve endothelial function in mice fed a high fat diet. Arch Biochem Biophys, 2014; 559: 46–52. https://doi.org/10.1016/j.abb.2014.02.005
  28. Song SJ, Choi S, Park T. Decaffeinated green coffee bean extract attenuates diet-induced obesity and insulin resistance in mice. Evidence-based Complementary and Alternative Medicine 2014; 2014: 718379. https://doi.org/10.1155/2014/718379
  29. Jia H, Aw W, Egashira K, Takahashi S, Aoyama S, Saito K et al. Coffee intake mitigated inflammation and obesity-induced insulin resistance in skeletal muscle of high-fat diet-induced obese mice. Genes Nutr, 2014; 9(3): 389. https://doi.org/10.1007/s12263-014-0389-3
  30. Takahashi S, Egashira K, Saito K, Jia H, Abe K, Kato H. Coffee intake down-regulates the hepatic gene expression of peroxisome proliferator-activated receptor gamma in C57BL/6J mice fed a high-fat diet. J Funct Foods, 2014; 6(1): 157–167. https://doi,org/10.1016/j.jff.2013.10.002
  31. Choi BK, Park SB, Lee DR, Lee HJ, Jin YY, Yang SH et al. Green coffee bean extract improves obesity by decreasing body fat in high-fat diet-induced obese mice. Asian Pac J Trop Med 2016; 9(7): 635–643. https://doi.org/10.1016/j.apjtm.2016.05.017
  32. Bhandarkar NS, Mouatt P, Brown L, Panchal SK. Green coffee ameliorates components of diet-induced metabolic syndrome in rats. J Funct Foods 2019; 57: 141–149. https://doi.org/10.1016/j.jff.2019.04.003
  33. Ilmiawati C, Fitri F, Rofinda Z, Reza M, Ilmiawati C, Fitri F et al. Green coffee extract modifies body weight, serum lipids and TNF-α in high-fat diet-induced obese rats. BMC Res Notes 2020; 13 (208). https://doi.org/10.1186/s13104-020-05052-y
  34. Velázquez AM, Roglans N, Bentanachs R, Gené M, Sala-Vila A, Lázaro I et al. Effects of a Low Dose of Caffeine Alone or as Part of a Green Coffee Extract, in a Rat Dietary Model of Lean Non-Alcoholic Fatty Liver Disease without Inflammation. Nutrients, 2020; 12(11): 1–19. https://doi.org/10.3390/nu12113240
  35. Christianty FM, Fajrin FA, Roni A. The potential effect of the green coffee extract on reducing atherogenic index in hyperlipidemic rats. Pharmacy Education, 2021; 21(2): 126–131. https://doi.org/10.46542/pe.2021.212.126131
  36. Farias-Pereira R, Oshiro J, Kim KH, Park Y. Green coffee bean extract and 5-O-caffeoylquinic acid regulate fat metabolism in Caenorhabditis elegans. J Funct Foods 2018; 48: 586–593. https://doi.org/10.1016/j.jff.2018.07.049
  37. AlAmri OD, Albeltagy RS, M. A. Akabawy A, Mahgoub S, Abdel-Mohsen DM, Abdel Moneim AE et al. Investigation of antioxidant and anti-inflammatory activities as well as the renal protective potential of green coffee extract in high fat-diet/streptozotocin-induced diabetes in male albino rats. J Funct Foods, 2020; 71: 103996. https://doi.org/10.1016/j.jff.2020.103996
  38. Lee IC, Lee JS, Lee JH, Kim Y, So WY. Anti-oxidative and anti-inflammatory activity of kenya grade aa green coffee bean extracts. Iran J Public Health, 2019; 48(11): 2025–2034. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961199/
  39. Funakoshi-Tago M, Nonaka Y, Tago K, Takeda M, Ishihara Y, Sakai A et al. Pyrocatechol, a component of coffee, suppresses LPS-induced inflammatory responses by inhibiting NF-κB and activating Nrf2. Sci Rep, 2020; 10: 2584. https://doi.org/10.1038/s41598-020-59380-x
  40. Tajik N, Tajik M, Mack I, Enck P. The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature. Eur J Nutr 2017; 56(7): 2215–2244. https://doi.org/10.1007/s00394-017-1379-1
  41. Ong KW, Hsu A, Tan BKH. Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation. Biochem Pharmacol, 2013; 85(9): 1341–1351. https://doi.org/10.1016/j.bcp.2013.02.008
  42. Onakpoya I, Terry R, Ernst E. The use of green coffee extract as a weight loss supplement: A systematic review and meta-analysis of randomised clinical trials. Gastroenterol Res Pract, 2011; 2011: 382852. https://doi.org/10.1155/2011/382852
  43. Vinson JA, Burnham BR, Nagendran M v. Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects. Diabetes Metab Syndr Obes, 2012; 5: 21–27. https://doi.org/10.2147/DMSO.S27665
  44. Xu J-G, Hu Q-P, Liu Y. Antioxidant and DNA-protective activities of chlorogenic acid isomers. J Agric Food Chem, 2012; 60: 11625–11630. https://doi.org/10.1021/jf303771s
  45. Amigoni L, Stuknytė M, Ciaramelli C, Magoni C, Bruni I, de Noni I et al. Green coffee extract enhances oxidative stress resistance and delays aging in Caenorhabditis elegans. J Funct Foods 2017; 33(3): 297–306. https://doi.org/10.1016/j.jff.2017.03.056
  46. Shah AD, Langenberg C, Rapsomaniki E, Denaxas S, Pujades-Rodriguez M, Gale CP et al. Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1·9 million people. Lancet Diabetes Endocrinol, 2015; 3(2): 105–113. https://doi.org/10.1016/S2213-8587(14)70219-0
  47. Meng S, Cao J, Feng Q, Peng J, Hu Y. Roles of chlorogenic acid on regulating glucose and lipids metabolism: a review. Evidence-based Complementary and Alternative Medicine, 2013; 2013. https://doi.org/10.1155/2013/801457
  48. Nishi N, Kumar P, Ahad A. Hypolipidemic effect of chlorogenic acid in a hypercholesterolemic rat model. Int J Pharma Bio Sci, 2013; 4(1): B582-B586
  49. Zulli A, Smith R, Kubatka P, Novak J, Uehara Y, Loftus H et al. Caffeine and cardiovascular diseases: critical review of current research. Eur J Nutr, 2016; 55(4): 1331–1343. https://doi.org/10.1007/s00394-016-1179-z
  50. Su SH, Shyu HW, Yeh YT, Chen KM, Yeh H, Su SJ. Caffeine inhibits adipogenic differentiation of primary adipose-derived stem cells and bone marrow stromal cells. Toxicol In Vitro 2013; 27(6): 1830–1837. https://doi.org/10.1016/j.tiv.2013.05.011
  51. Mohamadi N, Sharififar F, Pournamdari M, Ansari M. A Review on Biosynthesis, Analytical Techniques, and Pharmacological Activities of Trigonelline as a Plant Alkaloid. J Diet Suppl, 2018; 15(2): 207–222. https://doi.org/10.1080/19390211.2017.1329244
  52. Thom E. The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people. J Int Med Res 2007; 35(6): 900–908. https;//doi.org/10.1177/147323000703500620
  53. Johnston K, Clifford M, Morgan L. Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine. Am J Clin Nutr, 2003; 78(4): 728–733. https://doi.org/10.1093/ajcn/78.4.728
  54. Lelyana R. Underlying Mechanism of Coffee as Inhibitor Adipogenesis for Complementary Medicine Use in Obesity. J Nanomed Nanotechnol, 2017; 8: 1-3. https://doi.org/10.4172/2157-7439.1000425
  55. Kozuma K, Tsuchiya S, Kohori J, Hase T, Tokimitsu I. Antihypertensive effect of green coffee bean extract on mildly hypertensive subjects. Hypertens Res 2005; 28(9): 711–718. https://doi.org/10.1291/hypres.28.711
  56. Song S, Attia R, Connaughton S, Niesen M, Ness G, Elam M et al. Peroxisome proliferator activated receptor alpha (PPARalpha) and PPAR gamma coactivator (PGC-1alpha) induce carnitine palmitoyltransferase IA (CPT-1A) via independent gene elements. Mol Cell Endocrinol 2010; 325: 54–63. https://doi.org/10.1291/hypres.28.711
  57. Qiao L, Kinney B, Schaack J, Shao J. Adiponectin inhibits lipolysis in mouse adipocytes. Diabetes 2011; 60(5): 1519–1527. https://doi.org/10.2337/db10-1017
  58. Pecoraro É, Trovatti E, Chiari BG, Corrêa MA, Cicarelli RMB, Ribeiro SJL et al. Synergistic effect of green coffee oil and synthetic sunscreen for health care application. Ind Crops Prod 2014; 52: 389–393
  59. Marto J, Gouveia LF, Chiari BG, Paiva A, Isaac V, Pinto P et al. The green generation of sunscreens: Using coffee industrial sub-products. Ind Crops Prod, 2016; 80: 93–100. https://doi.org/10.1016/j.indcrop.2015.11.033

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