THE CORRELATION OF LONG-TERM COMBINATION TREATMENT OF VALPROIC ACID AND TOPIRAMATE ON SERUM VITAMIN D LEVELS AMONG CHILDREN WITH EPILEPSY

Hexanto Muhartomo; M.I Widiastuti; Endang Kustiowati; Aris Catur Bintoro; Arinta Puspita Wati; Alifiani Hikmah Putranti; Rony Parlindungan Sinaga

doi:10.14710/dmj.v11i1.32563

DOI: https://doi.org/10.14710/dmj.v11i1.32563

THE CORRELATION OF LONG-TERM COMBINATION TREATMENT OF VALPROIC ACID AND TOPIRAMATE ON SERUM VITAMIN D LEVELS AMONG CHILDREN WITH EPILEPSY

*Hexanto Muhartomo

- Department of Neurology, Faculty of Medicine, Diponegoro University/ dr Kariadi National Hospital Semarang, Indonesia

M.I Widiastuti - Department of Neurology, Faculty of Medicine, Diponegoro University/ dr Kariadi National Hospital Semarang, Indonesia

Endang Kustiowati - Department of Neurology, Faculty of Medicine, Diponegoro University/ dr Kariadi National Hospital Semarang, Indonesia

Aris Catur Bintoro - Department of Neurology, Faculty of Medicine, Diponegoro University/ dr Kariadi National Hospital Semarang, Indonesia

Arinta Puspita Wati - Department of Neurology, Faculty of Medicine, Diponegoro University/ dr Kariadi National Hospital Semarang, Indonesia

Alifiani Hikmah Putranti - Division of Neurology, Department of Pediatry, Faculty of Medicine, Diponegoro University/ dr. Kariadi National Hospital Semarang, Indonesia

Rony Parlindungan Sinaga - Department of Neurology, Faculty of Medicine, Diponegoro University/ dr Kariadi National Hospital Semarang, Indonesia

BibTex Citation Data :

@article{dmj32563,
    author = {Hexanto Muhartomo and M.I Widiastuti and Endang Kustiowati and Aris Bintoro and Arinta Wati and Alifiani Putranti and Rony Sinaga},
    title = {THE CORRELATION OF LONG-TERM COMBINATION TREATMENT OF VALPROIC ACID AND TOPIRAMATE ON SERUM VITAMIN D LEVELS AMONG CHILDREN WITH EPILEPSY},
    journal = {Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal)},
  volume = {11},
    number = {1},
    year = {2021},
    keywords = {Epylepsy, Valporic Acid, Vitamin D, Topiramate},
    abstract = {  Background:  Epilepsy is a chronic condition characterized by unprovoked seizure. Vitamin D is necessary in child development process and is strongly influenced by the presence of anti-epileptic drugs.   Objective:  To determine the correlation of treatment duration and serum vitamin D levels in children with epilepsy who use the combination of valproic acid and topiramate   Methods:  A cross sectional study among forty pediatric patients with epilepsy with age range of 5-10 years at Dr. Kariadi Hospital Semarang. Examination of serum vitamin D levels is done by ELISA. Statistical analysis using Spearman correlation test and partial correlation test with significance level p = 0.05.   Results:  The mean of serum vitamin D levels in patient with combination treatment after 24 months was 21.87±1.21ng/ml, in those who still having seizure was 27.94±2.40ng/ml, and among who received delayed therapy was 23.23±2.07ng/ml. Bivariate analysis depicted that there was negative correlation between duration of treatment (rho= -0.850, p<0.001), onset of therapy (rho=0.604, p<0.001) and seizure frequency (rho=0.559, p<0.001) with serum vitamin D levels. Partial correlation analysis showed a significant correlation between duration of treatment and serum vitamin D levels after adjusted by onset of therapy (rho=-0.839, p<0.001) and seizure frequency (rho=-0.856, p<0.001).   Conclusion:  There is a correlation between the duration of treatment and serum vitamin D levels among children with epilepsy },
   issn = {2540-8844},   pages = {12--18}  doi = {10.14710/dmj.v11i1.32563},
    url = {https://ejournal3.undip.ac.id/index.php/medico/article/view/32563}
}

Citation Format:

Abstract

Background: Epilepsy is a chronic condition characterized by unprovoked seizure. Vitamin D is necessary in child development process and is strongly influenced by the presence of anti-epileptic drugs.

Objective: To determine the correlation of treatment duration and serum vitamin D levels in children with epilepsy who use the combination of valproic acid and topiramate

Methods: A cross sectional study among forty pediatric patients with epilepsy with age range of 5-10 years at Dr. Kariadi Hospital Semarang. Examination of serum vitamin D levels is done by ELISA. Statistical analysis using Spearman correlation test and partial correlation test with significance level p = 0.05.

Results: The mean of serum vitamin D levels in patient with combination treatment after 24 months was 21.87±1.21ng/ml, in those who still having seizure was 27.94±2.40ng/ml, and among who received delayed therapy was 23.23±2.07ng/ml. Bivariate analysis depicted that there was negative correlation between duration of treatment (rho= -0.850, p<0.001), onset of therapy (rho=0.604, p<0.001) and seizure frequency (rho=0.559, p<0.001) with serum vitamin D levels. Partial correlation analysis showed a significant correlation between duration of treatment and serum vitamin D levels after adjusted by onset of therapy (rho=-0.839, p<0.001) and seizure frequency (rho=-0.856, p<0.001).

Conclusion: There is a correlation between the duration of treatment and serum vitamin D levels among children with epilepsy

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Keywords: Epylepsy, Valporic Acid, Vitamin D, Topiramate

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Section: Original Articles

Language : EN

In Vol 11, No 1 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)

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