DOI: https://doi.org/10.14710/dmj.v14i6.50802

EFFECT OF EXERCISE ON TRPV1 EXPRESSION IN THE MUSCLE OF GALUR WISTAR RATS

*Hanna Goenawan orcid scopus  -  Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Sumedang, Indonesia, Indonesia
Raisa Zahra  -  Bachelor Program of Medical Doctor, Faculty of Medicine, Universitas Padjadjaran, Sumedang, Indonesia, Indonesia
Putri Teesa Radhiyanti orcid scopus  -  Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Sumedang, Indonesia, Indonesia
Julia Ramadhanti  -  Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Sumedang, Indonesia, Indonesia
Vita Murniati Tarawan orcid scopus  -  Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Sumedang, Indonesia, Indonesia
Fifi Veronica orcid scopus  -  Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Sumedang, Indonesia, Indonesia
Open Access Copyright 2025 Hanna Goenawan, Raisa Zahra, Putri Teesa Radhiyanti Radhiyanti, Fifi Veronica, Vita Murniati Tarawan
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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Abstract

Background: Exercise is an activity that induces acid generation as one of the TRPV1 stimulants. Activation of TRPV1, a pain receptor, by acid, can lead to the formation of neuropeptides such as substance P and calcitonin gene-related peptides as a cause of inflammation and pain. However, chronic TRPV1 activation triggered by exercise can cause TRPV1 desensitization. Objective: Aim of this study was to examine the effect of different intensity exercise on TRPV1 mRNA expression in gastrocnemius muscle. Methods: This study was experimental study using animals models. Rats aged 12-24 weeks were given exercise interventions, a treadmill protocol, 5 times a week (30 min/day) with low (10 m/s), moderate (20 m/s), and high (30 m/s) intensity for 8 weeks. After exercise period, gastrocnemius muscle were isolated and subjected for TRPV1 mRNA expression analysis using semi quantitative real time PCR. Results: There was no changes of TRPV1 mRNA gene expression in gastrocnemius after treatment of different intensity exercise (p =0.694). Conclusion: As the conclusion, 8 weeks different intensity of exercise did not alter TRPV1 expression in gastrocnemius. 

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Keywords: chronic pain; desensitization; exercise; TRPV1

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Language : EN
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