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Bone Mineral Density and Vitamin D Status in Elderly Javanese Women

*Lusiana Batubara orcid scopus  -  Dept of Medical Biology and Biochemistry Faculty of Medicine Universitas Diponegoro Semarang, Indonesia
Faizah Fulyani  -  Dept of Medical Biology and Biochemistry Faculty of Medicine Universitas Diponegoro Semarang, Indonesia
Dwi Ngestiningsih  -  Dept of Medical Biology and Biochemistry Faculty of Medicine Universitas Diponegoro Semarang, Indonesia
Hermina Sukmaningtyas  -  Dept of Medical Radiology, Faculty of Medicine Universitas Diponegoro Semarang, Indonesia
Ainun Rahmasari Gumay  -  Department of Physiology Faculty of Medicine Diponegoro University Semarang, Indonesia
Etisa Adi Murbawani  -  5Department of Clinical Nutrition Faculty of Medicine Diponegoro University Semarang, Indonesia
Enny Probosari  -  5Department of Clinical Nutrition Faculty of Medicine Diponegoro University Semarang, Indonesia

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Background: Vitamin D (25OHD) works as a lipid-soluble secosteroid hormone essential for metabolic activities, including bone mineralization. 1,25OHD and its receptor are transcription factors for various bone homeostasis genes. Numerous studies have connected vitamin D insufficiency with a decline in bone mineral density (BMD), but the results are still conflicting. However, information on vitamin D insufficiency among Indonesian individuals is hardly available.

Objective: The study aims to evaluate vitamin D levels and their correlation with BMD among Javanese elderly women.

Methods: 75 healthy Javanese elderly women between 60 and 84 participated in a cross-sectional study. An enzyme-linked immunoassay kit for 25OHD was used to measure the level of serum vitamin D. DXA, or dual-energy X-ray absorptiometry, was used to measure BMD.

Results: The study population's mean serum 25OHD level was 14.97±6.6ng/mL. We found that 73.3% were deficient in vitamin D, and 26.7% were not. There is no correlation between vitamin D and BMD L-spine, F-neck, or T-score (p=0.064, -0.215; p=0.443, -0.090; and p=0.109, -0.187, respectively). Lower BMD L-spine, F-neck and T-score were correlated with increased age (r = -0.238, p = 0.040; r = -0.377, p = 0.001; and r = -0.295, p = 0.010, respectively) and decreased BMI (r = 0.525, p = 0.000; r = 0.516, p = 0.000; and r = 0.520, p = 0.000, respectively).

Conclusion: From this study, we concluded that vitamin D deficiency was prevalent among Javanese elderly women. However, the vitamin D level in this population and bone mineral density do not appear to be correlated.

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Keywords: BMD; DXA; elderly; vitamin D; 25OHD

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