BibTex Citation Data :
@article{dmj31588, author = {Salwa Izzati and Desy Armalina and RR. Mahayu Ariani and Fanti Saktini}, title = {Histopathology of Seminiferous Tubules of Wistar Rats (Rattus norvegicus) Exposed to Electric Mosquito Repellent with Active Ingredient D-Allethrin}, journal = {Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal)}, volume = {10}, number = {5}, year = {2021}, keywords = {Electrical mosquito repellent; d-allethrin; oxidative stress; seminiferous tubules; spermatogenesis}, abstract = { Background: An increase in mosquito-borne diseases has resulted in the use of mosquito repellents, especially electric ones in Indonesia. One of the active ingredients of electric mosquito repellent, namely d-allethrin , cangenerate free radicals resulting in oxidative stress. Oxidative stress on the testes can interfere with the spermatogenesis stage in the seminiferous tubules. Objective : Determine the histopathology of seminiferous tubules of Wistar rats exposed to electric mosquito repellents with the active ingredient d-allethrin . Method s : This study used a true experimental design with a post test only control group design. A sample of 25 Wistar rats was divided into 5 groups. The control group (K) was given only standard feed. Treatment group 1 (P1), treatment group 2 (P2), treatment group 3 (P3), and treatment group 4 (P4) were exposed to electric mosquito repellents with active ingredient d-allethrin sequentially for 8 hours/day, 12 hours/day, 18 hours/day, and 24 hours/day. After 30 days the rats were terminated. The testes were taken for histopathological observation with HE staining and assessed according to the Johnsen score criteria. Result s : Based on the score, the mean value of the control group was 9.4, P1: 8.36, P2: namely 7.68, P3: 5.84, and P4: 5.64.The results of statistical tests using the one way Anova showed a significant difference (p <0.001). Conclusion: Exposure to electric mosquito repellent containing the active ingredient d-allethrin caused differences in the histopathology of seminiferous tubules score of Wistar rats. }, issn = {2540-8844}, pages = {390--395} doi = {10.14710/dmj.v10i5.31588}, url = {https://ejournal3.undip.ac.id/index.php/medico/article/view/31588} }
Refworks Citation Data :
Background: An increase in mosquito-borne diseases has resulted in the use of mosquito repellents, especially electric ones in Indonesia. One of the active ingredients of electric mosquito repellent, namely d-allethrin, cangenerate free radicals resulting in oxidative stress. Oxidative stress on the testes can interfere with the spermatogenesis stage in the seminiferous tubules.
Objective: Determine the histopathology of seminiferous tubules of Wistar rats exposed to electric mosquito repellents with the active ingredient d-allethrin.
Methods: This study used a true experimental design with a post test only control group design. A sample of 25 Wistar rats was divided into 5 groups. The control group (K) was given only standard feed. Treatment group 1 (P1), treatment group 2 (P2), treatment group 3 (P3), and treatment group 4 (P4) were exposed to electric mosquito repellents with active ingredient d-allethrin sequentially for 8 hours/day, 12 hours/day, 18 hours/day, and 24 hours/day. After 30 days the rats were terminated. The testes were taken for histopathological observation with HE staining and assessed according to the Johnsen score criteria.
Results: Based on the score, the mean value of the control group was 9.4, P1: 8.36, P2: namely 7.68, P3: 5.84, and P4: 5.64.The results of statistical tests using the one way Anova showed a significant difference (p <0.001).
Conclusion: Exposure to electric mosquito repellent containing the active ingredient d-allethrin caused differences in the histopathology of seminiferous tubules score of Wistar rats.
Article Metrics:
Last update:
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) by http://ejournal3.undip.ac.id/index.php/medico/ is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
