BibTex Citation Data :
@article{dmj29955, author = {Maria Munthe and Novi Kusumaningrum and Amallia Setyawati and Astika Utomo and Santoso Santoso}, title = {CORRELATION OF INTERLEUKIN-23 SERUM LEVELS IN MEN WITH ACNE VULGARIS: A PRELIMINARY STUDY}, journal = {Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal)}, volume = {10}, number = {2}, year = {2021}, keywords = {Acne Vulgaris, Grade of Acne Vulgaris Severity, Interleukin-23}, abstract = { Background: Acne vulgaris (AV) is an inflammatory condition of pilosebaceous unit that is common in adolescents and young adults. The pathogenesis of AV is multifactorial, one of which is inflammation. Interleukin-23 (IL-23) has an important role in the activity of T helper 17 (Th17) cells that produce IL-17 in chronic inflammation. Objective: To determine the correlation between serum IL-23 levels and AV severity in men. Methods: This is an analytical observational preliminary study with a cross-sectional design involving 15 male subjects with AV who were divided into groups of AV severity based on Lehmann’s criteria. The subjects were examined for serum IL-23 levels. Data were analyzed using Spearman’s Rho non-parametric correlation test to determine the correlation between variables. Results: Mean IL-23 serum levels in men with AV was 111,05 ± 115,27 pg/ml, with mild AV was 210,57 ± 122,038 pg/ml, moderate AV was 103,65 ± 91,15 pg/ml and severe AV was 18,94 ± 15,76 pg/ml. There is a significant correlation between IL-23 serum levels and AV severity in men. (p = 0,001). Serum IL-23 levels decreased with increasing AV severity (r = -0,756). Conclusion: There is a strong negative correlation between IL-23 serum levels and AV severity in men. }, issn = {2540-8844}, pages = {156--160} doi = {10.14710/dmj.v10i2.29955}, url = {https://ejournal3.undip.ac.id/index.php/medico/article/view/29955} }
Refworks Citation Data :
Background: Acne vulgaris (AV) is an inflammatory condition of pilosebaceous unit that is common in adolescents and young adults. The pathogenesis of AV is multifactorial, one of which is inflammation. Interleukin-23 (IL-23) has an important role in the activity of T helper 17 (Th17) cells that produce IL-17 in chronic inflammation.
Objective: To determine the correlation between serum IL-23 levels and AV severity in men.
Methods: This is an analytical observational preliminary study with a cross-sectional design involving 15 male subjects with AV who were divided into groups of AV severity based on Lehmann’s criteria. The subjects were examined for serum IL-23 levels. Data were analyzed using Spearman’s Rho non-parametric correlation test to determine the correlation between variables.
Results: Mean IL-23 serum levels in men with AV was 111,05 ± 115,27 pg/ml, with mild AV was 210,57 ± 122,038 pg/ml, moderate AV was 103,65 ± 91,15 pg/ml and severe AV was 18,94 ± 15,76 pg/ml. There is a significant correlation between IL-23 serum levels and AV severity in men. (p = 0,001). Serum IL-23 levels decreased with increasing AV severity (r = -0,756).
Conclusion: There is a strong negative correlation between IL-23 serum levels and AV severity in men.
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