ANTIHYPERURICEMIC EFFECT OF RED GINGER POWDER AND LIME JUICE COMBINATION IN WISTAR RATS INDUCED HYPERURICEMIA

Eva Susanty Purba; Chikita Dian Rahma Saphira; Salma Yasmine Azzahara; Edwin Basyar; Muflihatul Muniroh; Ainun Rahmasari Gumay

doi:10.14710/dmj.v10i1.29374

DOI: https://doi.org/10.14710/dmj.v10i1.29374

ANTIHYPERURICEMIC EFFECT OF RED GINGER POWDER AND LIME JUICE COMBINATION IN WISTAR RATS INDUCED HYPERURICEMIA

Eva Susanty Purba - Undergraduate Program, Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Chikita Dian Rahma Saphira - Undergraduate Program, Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Salma Yasmine Azzahara - Undergraduate Program, Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Edwin Basyar - Department of Physiology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Muflihatul Muniroh - Department of Physiology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia

*Ainun Rahmasari Gumay - Department of Physiology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia

BibTex Citation Data :

@article{dmj29374,
    author = {Eva Purba and Chikita Saphira and Salma Azzahara and Edwin Basyar and Muflihatul Muniroh and Ainun Gumay},
    title = {ANTIHYPERURICEMIC EFFECT OF RED GINGER POWDER AND LIME JUICE COMBINATION IN WISTAR RATS INDUCED HYPERURICEMIA},
    journal = {Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal)},
  volume = {10},
    number = {1},
    year = {2021},
    keywords = {Hyperuricemia, red ginger, lime juice, potassium oxonate},
    abstract = {  Background:  Hyperuricemia is an abnormally high level of uric acid in the blood. Ginger and lime are natural ingredients that contain antioxidants and anti-inflammatory which could reduce blood uric acid levels. This study aims to prove the effect of red ginger powder and lime juice combination on uric acid levels of Wistar rats induced hyperuricemia.   Methods:  Experimental research with pre and post-test only control group design. Thirty Wistar male   rats,   aged 2-3 months, weighed 150-350 grams randomly divided into 5 groups. Group C1 was   normal control group. Group C2 was induced by single intraperitoneal injection of potassium   oxonate (300mg/kgBW). Group T1, T2, T3 were induced by potassium oxonate and orally   administered by combination of red ginger powder (300, 600, 1200 mg/200gBW) and lime juice   (2ml/150gBW). Blood samples in each group will be collected in 1 hour after treatment. Uric   acid levels were measured using the TBHBA uric acid method.   Results:  Uric acid level in   T1, T2, and T3 group was significantly lower than C2 group (p<0,05). The most effective dose   to reduce uric acid levels was 1200mg/200gBW red ginger in combination with 2ml/150gBW lime juice (T3 group).   Conclusion:  Red ginger powder and   lime juice may reduce the blood uric acid levels in Wistar rats induced hyperuricemia. },
   issn = {2540-8844},   pages = {69--73}  doi = {10.14710/dmj.v10i1.29374},
    url = {https://ejournal3.undip.ac.id/index.php/medico/article/view/29374}
}

Citation Format:

Abstract

Background: Hyperuricemia is an abnormally high level of uric acid in the blood. Ginger and lime are natural ingredients that contain antioxidants and anti-inflammatory which could reduce blood uric acid levels. This study aims to prove the effect of red ginger powder and lime juice combination on uric acid levels of Wistar rats induced hyperuricemia.

Methods: Experimental research with pre and post-test only control group design. Thirty Wistar male rats, aged 2-3 months, weighed 150-350 grams randomly divided into 5 groups. Group C1 was normal control group. Group C2 was induced by single intraperitoneal injection of potassium oxonate (300mg/kgBW). Group T1, T2, T3 were induced by potassium oxonate and orally administered by combination of red ginger powder (300, 600, 1200 mg/200gBW) and lime juice (2ml/150gBW). Blood samples in each group will be collected in 1 hour after treatment. Uric acid levels were measured using the TBHBA uric acid method.

Results: Uric acid level in T1, T2, and T3 group was significantly lower than C2 group (p<0,05). The most effective dose to reduce uric acid levels was 1200mg/200gBW red ginger in combination with 2ml/150gBW lime juice (T3 group).

Conclusion: Red ginger powder and lime juice may reduce the blood uric acid levels in Wistar rats induced hyperuricemia.

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Keywords: Hyperuricemia, red ginger, lime juice, potassium oxonate

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Section: Original Articles

Language : EN

In Vol 10, No 1 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)

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