skip to main content

DETEKSI YERSINIA PESTIS DAN PATOGEN ZOONOTIK LAINNYA PADA TIKUS DI DAERAH FOKUS PES DESA KAYUKEBEK KABUPATEN PASURUAN

Arief Mulyono scopus  -  Pusat Riset Kesehatan Masyarakat dan Gizi, Organisasi Riset Kesehatan, Badan Riset dan Inovasi Nasional, Cibinong Science Center, Jl. Raya Jakarta-Bogor, Pakansari, Kec. Cibinong, Kabupaten Bogor, Jawa Barat, Indonesia 16915 | Badan Riset dan Inovasi Nasional, Indonesia
Muhammad Choirul Hidajat orcid scopus  -  Pusat Riset Kesehatan Masyarakat dan Gizi, Organisasi Riset Kesehatan, Badan Riset dan Inovasi Nasional, Cibinong Science Center, Jl. Raya Jakarta-Bogor, Pakansari, Kec. Cibinong, Kabupaten Bogor, Jawa Barat, Indonesia 16915 | Badan Riset dan Inovasi Nasional, Indonesia
Ristiyanto Ristiyanto scopus  -  Pusat Riset Kesehatan Masyarakat dan Gizi, Organisasi Riset Kesehatan, Badan Riset dan Inovasi Nasional, Cibinong Science Center, Jl. Raya Jakarta-Bogor, Pakansari, Kec. Cibinong, Kabupaten Bogor, Jawa Barat, Indonesia 16915 | Badan Riset dan Inovasi Nasional, Indonesia
*Dian Eka Setyaningtyas orcid scopus  -  Pusat Riset Kesehatan Masyarakat dan Gizi, Organisasi Riset Kesehatan, Badan Riset dan Inovasi Nasional, Cibinong Science Center, Jl. Raya Jakarta-Bogor, Pakansari, Kec. Cibinong, Kabupaten Bogor, Jawa Barat, Indonesia 16915 | Badan Riset dan Inovasi Nasional, Indonesia
RA Wigati  -  Pusat Riset Kesehatan Masyarakat dan Gizi, Organisasi Riset Kesehatan, Badan Riset dan Inovasi Nasional, Cibinong Science Center, Jl. Raya Jakarta-Bogor, Pakansari, Kec. Cibinong, Kabupaten Bogor, Jawa Barat, Indonesia 16915 | Badan Riset dan Inovasi Nasional, Indonesia
Dimas Bagus Wicaksono Putro  -  Balai Besar Penelitian dan Pengembangan Vektor dan Reservoir Penyakit , Indonesia
Arum Sih Joharina  -  Balai Besar Penelitian dan Pengembangan Vektor dan Reservoir Penyakit , Indonesia
Ayu Pradipta Pratiwi  -  Balai Besar Penelitian dan Pengembangan Vektor dan Reservoir Penyakit , Indonesia
Muhidin Muhidin  -  Balai Besar Penelitian dan Pengembangan Vektor dan Reservoir Penyakit , Indonesia
Bernardus Yuliadi  -  Balai Besar Penelitian dan Pengembangan Vektor dan Reservoir Penyakit , Indonesia
Received: 9 Aug 2023; Published: 30 Mar 2024.

Citation Format:
Abstract

Rats are known as carriers and transmissions of zoonotic diseases. About 60 types of zoonotic diseases that rats can transmit to humans. Some zoonotic diseases are Plague, Leptospirosis, Orthohantavirus infection, and Hepatitis E virus. This research aims to detect the bacteria Yersinia pestis, Leptospira, Hepatitis E virus, and Orthohantavirus in rats in Kayu Kebek Village, Pasuruan Regency. The research design used in this study is descriptive with a cross-sectional approach. The rats were captured for three days, two nights in the house, the neighborhood around the house, and the forest. The captured mice were identified as specimens of blood, spleen, kidneys, and liver. Detection of Yersinia pestis, Leptospira, and Hepatitis E is performed using PCR, while the detection of Orthohantavirus is performed using the ELISA method. A total of 45 mice were trapped, consisting of 2 genera and three species. The zoonotic pathogens detected were Leptospira and hepatitis E. Leptospira viruses were detected in Rattus tanezumi, Rattus tiomanicus, and Niviventer fluvescent. Hepatitis E virus is detected only in R. tanezumi. Transmission of leptospirosis and hepatitis E has the potential to occur in Kayu Kebek Village. Rat control is needed to prevent the transmission of leptospirosis and hepatitis E virus infection, and other zoonotic diseases transmitted by rats.

Fulltext
Keywords: Plague, Leptospirosis, Orthohantavirus, Hepatitis E

Article Metrics:

  1. Meerburg BG, Singleton GR, Kijlstra A. Rodent-borne diseases and their risks for public health Rodent-borne diseases and their risks for public health. Vol. 35, Critical Reviews in Microbiology. 2009. 221–270 p
  2. Han BA, Schmidt JP, Bowden SE, Drake JM. Rodent reservoirs of future zoonotic diseases. Proc Natl Acad Sci U S A. 2015;112(22):7039–44
  3. Kurucz K, Madai M, Hederics D, Bali D, Kemenesi G, Jakab F. Molecular survey of zoonotic agents in rodents from an urban environment, Hungary. Int J Infect Dis. 2019;79(2019):67–8
  4. Costa F, Hagan JE, Calcagno J, Kane M, Torgerson P, Martinez-Silveira MS, et al. Global Morbidity and Mortality of Leptospirosis: A Systematic Review. PLoS Negl Trop Dis. 2015;9(9):0–1
  5. Vincent AT, Schiettekatte O, Goarant C, Neela VK, Bernet E, Thibeaux R, et al. Revisiting the taxonomy and evolution of pathogenicity of the genus Leptospira through the prism of genomics. PLoS Negl Trop Dis. 2019;13(5)
  6. Levett PN. Leptospira and Leptospirosis. Vol. 387. 2015. 65–97 p
  7. Kamar N, Selves J, Mansuy J-M, Ouezzani L, Péron J-M, Guitard J, et al. Hepatitis E Virus and Chronic Hepatitis in Organ-Transplant Recipients. N Engl J Med. 2008;358(8):811–7
  8. Sridhar S, Chan JFW, Yap DYH, Teng JLL, Huang C, Yip CCY, et al. Genotype 4 hepatitis E virus is a cause of chronic hepatitis in renal transplant recipients in Hong Kong. J Viral Hepat. 2018;25(2):209–13
  9. Kamar N, Dalton HR, Abravanel F, Izopet J. Hepatitis E virus infection. Clin Microbiol Rev. 2014;27(1):116–38
  10. Sridhar S, Yip CCY, Wu S, Cai J, Zhang AJX, Leung KH, et al. Rat hepatitis E virus as cause of persistent hepatitis after liver transplant. Emerg Infect Dis. 2018;24(12):2241–50
  11. Suyanto A. Lipi-Seri Panduan Lapangan: Rodent di Jawa. Bogor: Pusat Penelitian Biologi LIPI; 2006
  12. Ristiyanto R, Lisdawati V, Mulyono A, Handayani FD, Putro DBW, Sari TF, et al. Pedoman Pengumpulan Data Reeservoir (Tikus) di Lapangan. 3rd ed. Achmadi AS, Pamungkas J, Sinaga, editors. Jakarta: Lembaga Penerbit Badan Penelitan dan Pengembangan Kesehatan Kementerian Kesehatan RI; 2017. 1–666 p
  13. Johne R, Plenge-Bönig A, Hess M, Ulrich RG, Reetz J, Schielke A. Detection of a novel hepatitis E-like virus in faeces of wild rats using a nested broad-spectrum RT-PCR. J Gen Virol. 2010;91(3):750–8
  14. Ristiyanto, Mulyono A, Sih Joharina A, Dwi Handayani F, Pradipta A, Rosavika Kinansih R. Korelasi Densitas Relatif Tikus, Pinjal dan Curah Hujan Terhadap Kasus Pes di Daerah Enzootik Pes Taman Nasional Gunung Bromo Tengger, Pasuruan, Jawa Timur. J Biol Indones. 2020;16(2):217–25
  15. Pham H V., Dang DT, Tran minh NN, Nguyen ND, Nguyen T V. Correlates of environmental factors and human plague: An ecological study in vietnam. Int J Epidemiol. 2009;38(6):1634–41
  16. Adamovicz JJ, Worsham PL. Plague. Biodefense Research Methodology and Animal Models, Second Edition. 2012. 113–146 p
  17. Ivanova S, Herbreteau V, Blasdell K, Chaval Y, Buchy P, Guillard B, et al. Leptospira and rodents in Cambodia: Environmental determinants of infection. Am J Trop Med Hyg. 2012;86(6):1032–8
  18. Supranelfy Y, S NH, Oktarina R. Analysis of environmental factors on distribution of rats which confirmed as reservoir in three districts In South Sumatera Province. Vektora J Vektor dan Reserv Penyakit. 2019;11(1):31–8
  19. Lobo LT, Koraag ME, Widjaja J, Joharina AS, Pratiwi AP. Leptospirosis on Rats in Minahasa District, North Sulawesi 2016. J Vektor Penyakit. 2020;14(2):95–102
  20. Joharina AS, Pujiyanti A, Nugroho A, Martiningsih I, Handayani FD. Role of rats in leptospirosis transmission in three types ecosistem in Bantul District, Yogyakarta. Bul Penelit Kesehat. 2019;47(3):191–8
  21. Wibawa T, Wijayanti MA, Anastasia H. Detection of Leptospira spp . in kidney tissues isolated from rats in the Napu and Bada Highlands of Poso District, Central Sulawesi. J Vektor Penyakit. 2020;14(1):17–26
  22. Kenneth B, Shiokawa K, Sreekumari R. Leptospira infection in rats : A literature review of global prevalence and distribution. PLoS Negl Trop Dis. 2019;13(8):1–24
  23. Mulyono A, Sari TF, Yuliadi B, Royandi E, Pradipta A. Detection of Hepatitis E Virus and Hantavirus in animal reservoirs (rats) distributed in Klaten and Kendal Districts, Central Java Province. 2019;87–94
  24. Mulyanto, Depamede SN, Sriasih M, Takahashi M, Nagashima S, Jirintai S, et al. Frequent detection and characterization of hepatitis E virus variants in wild rats (Rattus rattus) in Indonesia. Arch Virol. 2013;158(1):87–96
  25. Li W, Guan D, Su J, Takeda N, Wakita T, Li TC, et al. High prevalence of rat hepatitis E virus in wild rats in China. Vet Microbiol. 2013;165(3–4):275–80
  26. Johne R, Heckel G, Plenge-Bönig A, Kindler E, Maresch C, Reetz J, et al. Novel hepatitis E virus genotype in Norway rats, Germany. Emerg Infect Dis. 2010;16(9):1452–5
  27. Johne R, Plenge-Bönig A, Hess M, Ulrich RG, Reetz J, Schielke A. Detection of a novel hepatitis E-like virus in faeces of wild rats using a nested broad-spectrum RT-PCR. J Gen Virol. 2010 Mar;91(Pt 3):750–8
  28. Ryll R, Bernstein S, Heuser E, Schlegel M, Dremsek P, Zumpe M, et al. Detection of rat hepatitis E virus in wild Norway rats (Rattus norvegicus) and Black rats (Rattus rattus) from 11 European countries. Vet Microbiol. 2017 Sep;208:58–68
  29. Simanavicius M, Juskaite K, Verbickaite A, Jasiulionis M, Tamosiunas PL, Petraityte-Burneikiene R, et al. Detection of rat hepatitis E virus, but not human pathogenic hepatitis E virus genotype 1-4 infections in wild rats from Lithuania. Vet Microbiol. 2018 Jul;221:129–33
  30. Andonov A, Robbins M, Borlang J, Cao J, Hatchette T, Stueck A, et al. Rat Hepatitis e Virus Linked to Severe Acute Hepatitis in an Immunocompetent Patient. J Infect Dis. 2019;220(6):951–5

Last update:

No citation recorded.

Last update:

No citation recorded.