THE CORRELATION OF LONG-TERM COMBINATION TREATMENT OF VALPROIC ACID AND TOPIRAMATE ON SERUM VITAMIN D LEVELS AMONG CHILDREN WITH EPILEPSY

Hexanto Muhartomo; M.I Widiastuti; Endang Kustiowati; Aris Catur Bintoro; Arinta Puspita Wati; Alifiani Hikmah Putranti; Rony Parlindungan Sinaga

doi:10.14710/dmj.v11i1.32563

DOI: https://doi.org/10.14710/dmj.v11i1.32563

THE CORRELATION OF LONG-TERM COMBINATION TREATMENT OF VALPROIC ACID AND TOPIRAMATE ON SERUM VITAMIN D LEVELS AMONG CHILDREN WITH EPILEPSY

*Hexanto Muhartomo

- Department of Neurology, Faculty of Medicine, Diponegoro University/ dr Kariadi National Hospital Semarang, Indonesia

M.I Widiastuti - Department of Neurology, Faculty of Medicine, Diponegoro University/ dr Kariadi National Hospital Semarang, Indonesia

Endang Kustiowati - Department of Neurology, Faculty of Medicine, Diponegoro University/ dr Kariadi National Hospital Semarang, Indonesia

Aris Catur Bintoro - Department of Neurology, Faculty of Medicine, Diponegoro University/ dr Kariadi National Hospital Semarang, Indonesia

Arinta Puspita Wati - Department of Neurology, Faculty of Medicine, Diponegoro University/ dr Kariadi National Hospital Semarang, Indonesia

Alifiani Hikmah Putranti - Division of Neurology, Department of Pediatry, Faculty of Medicine, Diponegoro University/ dr. Kariadi National Hospital Semarang, Indonesia

Rony Parlindungan Sinaga - Department of Neurology, Faculty of Medicine, Diponegoro University/ dr Kariadi National Hospital Semarang, Indonesia

BibTex Citation Data :

@article{dmj32563,
    author = {Hexanto Muhartomo and M.I Widiastuti and Endang Kustiowati and Aris Bintoro and Arinta Wati and Alifiani Putranti and Rony Sinaga},
    title = {THE CORRELATION OF LONG-TERM COMBINATION TREATMENT OF VALPROIC ACID AND TOPIRAMATE ON SERUM VITAMIN D LEVELS AMONG CHILDREN WITH EPILEPSY},
    journal = {Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal)},
  volume = {11},
    number = {1},
    year = {2021},
    keywords = {Epylepsy, Valporic Acid, Vitamin D, Topiramate},
    abstract = {  Background:  Epilepsy is a chronic condition characterized by unprovoked seizure. Vitamin D is necessary in child development process and is strongly influenced by the presence of anti-epileptic drugs.   Objective:  To determine the correlation of treatment duration and serum vitamin D levels in children with epilepsy who use the combination of valproic acid and topiramate   Methods:  A cross sectional study among forty pediatric patients with epilepsy with age range of 5-10 years at Dr. Kariadi Hospital Semarang. Examination of serum vitamin D levels is done by ELISA. Statistical analysis using Spearman correlation test and partial correlation test with significance level p = 0.05.   Results:  The mean of serum vitamin D levels in patient with combination treatment after 24 months was 21.87±1.21ng/ml, in those who still having seizure was 27.94±2.40ng/ml, and among who received delayed therapy was 23.23±2.07ng/ml. Bivariate analysis depicted that there was negative correlation between duration of treatment (rho= -0.850, p<0.001), onset of therapy (rho=0.604, p<0.001) and seizure frequency (rho=0.559, p<0.001) with serum vitamin D levels. Partial correlation analysis showed a significant correlation between duration of treatment and serum vitamin D levels after adjusted by onset of therapy (rho=-0.839, p<0.001) and seizure frequency (rho=-0.856, p<0.001).   Conclusion:  There is a correlation between the duration of treatment and serum vitamin D levels among children with epilepsy },
   issn = {2540-8844},   pages = {12--18}  doi = {10.14710/dmj.v11i1.32563},
    url = {https://ejournal3.undip.ac.id/index.php/medico/article/view/32563}
}

Citation Format:

Abstract

Background: Epilepsy is a chronic condition characterized by unprovoked seizure. Vitamin D is necessary in child development process and is strongly influenced by the presence of anti-epileptic drugs.

Objective: To determine the correlation of treatment duration and serum vitamin D levels in children with epilepsy who use the combination of valproic acid and topiramate

Methods: A cross sectional study among forty pediatric patients with epilepsy with age range of 5-10 years at Dr. Kariadi Hospital Semarang. Examination of serum vitamin D levels is done by ELISA. Statistical analysis using Spearman correlation test and partial correlation test with significance level p = 0.05.

Results: The mean of serum vitamin D levels in patient with combination treatment after 24 months was 21.87±1.21ng/ml, in those who still having seizure was 27.94±2.40ng/ml, and among who received delayed therapy was 23.23±2.07ng/ml. Bivariate analysis depicted that there was negative correlation between duration of treatment (rho= -0.850, p<0.001), onset of therapy (rho=0.604, p<0.001) and seizure frequency (rho=0.559, p<0.001) with serum vitamin D levels. Partial correlation analysis showed a significant correlation between duration of treatment and serum vitamin D levels after adjusted by onset of therapy (rho=-0.839, p<0.001) and seizure frequency (rho=-0.856, p<0.001).

Conclusion: There is a correlation between the duration of treatment and serum vitamin D levels among children with epilepsy

Fulltext View|Download

Keywords: Epylepsy, Valporic Acid, Vitamin D, Topiramate

Article Metrics:

Article Info

Section: Original Articles

Language : EN

In Vol 11, No 1 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)

Recent articles

ASSOCIATION BETWEEN THE DEGREE OF DIABETIC RETINOPATHY AND DIABETIC MACULAR EDEMA THE EFFECT OF 0.12% CHLORHEXIDINE DIGLUCONATE AND 0.1% CHLORINE DIOXIDE ON DISCOLORATION OF NANOFILLED COMPOSITE RESIN EFFECT OF DIFFERENT CONCENTRATION CINNAMON EXTRACTS (CINNAMOMUM BURMANNII) IN GROWTH LACTOBACILLUS ACIDOPHILUS (IN VITRO) More recent articles

Last update:

No citation recorded.

Last update:

No citation recorded.

Authors who publish with this journal agree to the following terms: - Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (CC-BY-NC-SA) that allows others to share the work with an acknowledgment of the work’s authorship and initial publication in this journal. - Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal. - Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).