DOI: https://doi.org/10.14710/dmj.v14i5.49050

DIFFERENTIATING APPENDICITIS TYPES: THE ROLE OF NEUTROPHIL SUBTYPES

*Helman Kurniadi orcid  -  Universitas Adiwangsa Jambi, Indonesia
Timbul Partogi Haposan Simorangkir  -  1. Gatot Soebroto Army Central Hospital, Indonesia , Indonesia
Open Access Copyright 2025 Helman Kurniadi, Timbul Partogi Haposan Simorangkir
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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Abstract

Background: Recent studies have highlighted the significance of inflammatory markers in diagnosing appendicitis; however, the specific roles of stab and segmented neutrophils in assessing disease severity remain poorly understood. Objective: This study aims to analyze the relationship between the types of appendicitis (complicated and uncomplicated) and neutrophil counts (stab and segmented), along with demographic variables such as age and gender, to evaluate their diagnostic significance. Methods: A retrospective, descriptive study was conducted on 48 appendicitis patients treated at Gatot Soebroto Army Central Hospital during 2020–2021. Data were analyzed using the Mann-Whitney U test, with a significance threshold set at p<0.05. Results: Neutrophil segment counts demonstrated a statistically significant difference between complicated and uncomplicated appendicitis cases (p=0.000), with higher levels observed in complicated cases. In contrast, neutrophil stab counts, age, and gender did not show statistically significant differences (p>0.05). Conclusion: Neutrophil segment counts serve as a reliable marker for assessing appendicitis severity, while neutrophil stab counts and demographic factors such as age and gender lack predictive value. Further research is warranted to investigate the temporal dynamics of neutrophil levels and their integration with other inflammatory markers.

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Keywords: Appendicitis, biomarkers, complications, neutrophil segment, neutrophil stab

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Section: Original Articles
Language : EN
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  3. Ferris M, Quan S, Kaplan BS, Molodecky NA, Ball CG, Chernoff GW, et al. Global variation in the epidemiology of appendicitis: a systematic review. World Journal of Surgery. 2017;41(9):2273-2281. https://doi.org/10.1007/s00268-017-4022-1
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  5. Humes DJ, Simpson J. Acute appendicitis. BMJ. 2019;333(7567):530-534. https://doi.org/10.1136/bmj.38940.664363.AE
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  7. Markar SR, Karthikesalingam A, Falzon A, Kanakala V. The role of inflammatory markers in predicting severity of appendicitis. Annals of Surgery. 2019;269(6):34-41. https://doi.org/10.1097/SLA.0000000000003410
  8. Widodo T, Budiman B, Rahmat R, Alamsyah R. Faktor risiko komplikasi pada radang usus buntu. Jurnal Diagnostik Indonesia. 2018;10(4):89-95
  9. Ferris M, Quan S, Kaplan BS, Haggerty S, Molodecky NA, Pieroni P, et al. The global incidence of appendicitis: a systematic review of population-based studies. Annals of Surgery. 2017;266(2):237-241. https://doi.org/10.1097/SLA.A0000000000002188
  10. Hidayat R, Pratama A. Analisis neutrofil pada kasus radang usus buntu. Jurnal Medis Indonesia. 2019;8(2):45-52
  11. Sutton JT, Assar MJ, Lapidus N. Timing of biomarker evaluation and its impact on the diagnosis of appendicitis. Journal of Emergency Medicine. 2020;59(4):521-529. https://doi.org/10.1016/j.jemermed.2020.06.012
  12. Putri DA, Pratama A, Suryadi T. Biomarker laboratorium pada diagnosis apendisitis. Jurnal Kedokteran Nusantara. 2021;12(1):67-74
  13. Santoso B, Andriana A, Rahman TA. Peran jumlah segmen neutrofil dalam menentukan keparahan apendisitis. Jurnal Kesehatan Tropis. 2020;15(3):112-119
  14. Lestari E, Nugroho A. Pengaruh waktu diagnosis terhadap keparahan apendisitis. Jurnal Ilmiah Kedokteran. 2017;9(1):33-41
  15. Andersson RE, Hugander A, Thulin AJ, Nystrom PO, Olaison G. Diagnostic accuracy and the predictive value of laboratory tests in patients with suspected acute appendicitis. Annals of Surgery. 2018;227(3):301-308. https://doi.org/10.1097/00000658-201803000-00008
  16. Rivera-Chávez FA, Pettigrew C, Chandler NM. Biomarkers in the diagnosis of acute appendicitis: systematic review and meta-analysis. World Journal of Surgery. 2022;46(3):567-576. https://doi.org/10.1007/s00268-021-06284-3
  17. World Health Organization (WHO). Management of acute appendicitis: global guidelines. Geneva: WHO Press; 2021

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